The Morris Lab at the Donnelly Centre for Cellular and Biomolecular Research and the University of Toronto is officially open for business, and the lab website is live! Check it out for info on our research and how you can join: morris-lab.org

Recent trend in AI/genomics/LLM space is just to show a model is bigger. Then the paper finishes w/o rigorous benchmarking to show the bigger model is functionally superior in important downstream applications vs smaller SOTA models. Laughably sad state of field, don't be fooled.

Folks at #BoG23 and others - I'm recruiting postdocs to my Stockholm and New York teams. Reach out if interested - experimental or computational opportunities in gene expression dosage (talk #39), GWAS+CRISPR+molQTLs, developmental GTEx, etc.
science.org/doi/10.1126/sc…

Philipp Rentzsch #GRD23 : Many diseases are caused by changes in gene dosage. Genes have varying levels of gene expression in the population. V^G is a metric of dosage variation (introduced here:
pubmed.ncbi.nlm.nih.gov/31601707/)

Now found that haploinsufficient genes have smaller V^G.

Excited to announce that our paper 'Dynamic DNA methylation reveals novel cis-regulatory elements in mouse hematopoiesis' is now online at Experimental Hematology - including a DNAme array map of murine hematopoiesis! ISEH Translational Cancer Epigenomics Daniel Lipka (@dblipka.bsky.social)
exphem.org/article/S0301-…

kircherlab.github.io is recruiting 2 PostDocs (tinyurl.com/HLpostDoc. tinyurl.com/igvfHLpostDoc). Apply by Oct 10, 22. We are part of #IGVF , analyze reg. variant effects (MPRAs/CRISPR screens) and develop new comp. models & tools w/ Jay Shendure, Nadav Ahituv, Malte Spielmann.

Science media: still tweeting about a terribly designed, underpowered study a week later because it has cool photos and gets clicks.

Also science media: what drives scientists to publish studies that don’t replicate???

A framework to score the effects of structural variants in health and disease | Genome Research
genome.cshlp.org/content/32/4/7…

#Bioinformatics

We're looking for a postdoc in Stockholm! Co-mentored position at the intersection of biology/genomics and ML. Fantastic environment at KTH Royal Institute of Technology & SciLifeLab's Data Driven Life Science community, with strong international networks. Please RT!
kth.se/en/om/work-at-…

What was missing from the game we all love? A Gene Symbol version. Want to be a #bioinformatician , or simple love #genetics , this is the nearly impossible guess the gene game you always wanted but never asked for.

Biology at York Royal Society of Biology #compsci

andrewholding.github.io/gene-wordle/

CADD-SV - a framework to score the effects of structural variants in health and disease biorxiv.org/cgi/content/sh… #bioRxiv

New tracks are available for human assemblies, hg19 and hg38. The new tracks show Combined Annotation Dependent Depletion (CADD) scores for each base in the genome and correspond to the v1.6 developmental release.

Read more about the release at: genome.ucsc.edu/goldenPath/new…

#CADD

Hello #ESHG2020 , visit me at my poster P17.121.B virtualcongress.ctimeetingtech.com/eshg2020/atten… to talk about the newest CADD version CADD-Splice. I am opening a zoom video chat, come and join me!