Combining circulating absolute monocyte count and a 4-gene monocyte signature at leukapheresis predicts PFS of LBCL receiving CAR T cells. ow.ly/nEKc50RyQvo #lymphoidneoplasia #immunobiologyandimmunotherapy

RLYB331 is a human antibody that increases hepcidin, reduces iron overload, and ameliorates ineffective erythropoiesis in β-thalassemia. ow.ly/WXW350RyPp8 #redcellsironanderythropoiesis

ABC subtype sinonasal DLBCL is part of a superordinate family of MCD lymphomas, presenting at immune-privileged and other extranodal sites. ow.ly/FJjV50RyP9s #lymphoidneoplasia

BCR cross-linking activates a positive feedback loop including NAMPT and sirtuins and converging on AKT activation. ow.ly/Q4yz50RyP6a #lymphoidneoplasia

Imatinib resistance at diagnosis was higher in cells of patients who relapsed vs those in remission after imatinib and chemotherapy. ow.ly/gQfK50RyP0f #lymphoidneoplasia #clinicaltrialsandobservations

Immunotherapies can be studied in a syngeneic or an allogeneic setting after stem cell transplant. ow.ly/tflQ50RyOSU #immunobiologyandimmunotherapy #lymphoidneoplasia

Human FcγRIII monovalent blocking as a 1-armed antibody or albumin fusion protein are effective in a humanized model of ITP. ow.ly/2rMV50RyOPa #immunobiologyandimmunotherapy

The novel EHA/EBMT grading of ICAHT closely reflects the extent of hematological toxicity following BCMA- and CD19-directed CAR-T therapy. ow.ly/f11U50RyOJ2 #immunobiologyandimmunotherapy #hematopoiesisandstemcells #lymphoidneoplasia

Immune reconstitution profiles could inform optimal influenza vaccination timing after pediatric HCT. ow.ly/LePc50RyOEB #transplantation #hematopoiesisandstemcells

GF, age at HCT, prior history of VOC, and donor type are major contributory factors for the recurrence of vaso-occlusive episodes. ow.ly/aU8850RyOzP #transplantation #redcellsironanderythropoiesis

MAGIC biomarkers at first CR/VGPR can predict GVHD flares. ow.ly/eLM450RyOuH #transplantation

The monovalent albumin fusion protein showed no AEs, whereas the Fc-impaired 1-armed antibody induced minor changes in body temperature. ow.ly/UCXn50Rn4gP #immunobiologyandimmunotherapy

Severe ICAHT was associated with transfusion use, an increased rate of severe infections and adverse treatment outcomes with high NRM. ow.ly/6okA50Rn4bz #immunobiologyandimmunotherapy #hematopoiesisandstemcells #lymphoidneoplasia

Monocytes depletion from apheresis products could result in improved outcome of patients with R/R LBCL receiving CD19–directed CAR T cells. ow.ly/HLHO50Rn45A #lymphoidneoplasia #immunobiologyandimmunotherapy

New mouse model allows for side-by-side comparison of antitumor activity and side effects of immunotherapeutics targeting the same epitope. ow.ly/zM5g50RmtwN #

In publications on BTK and its inhibitors, phosphorylation of tyrosine 223 is often considered necessary for complete catalytic activity. ow.ly/p5nV50Rmttj #immunobiologyandimmunotherapy #lymphoidneoplasia

HSC and HPC require autophagy to overcome stressors in the GVHD setting in order to successfully engraft and reconstitute the bone marrow. ow.ly/gEkR50Rmtni #immunobiologyandimmunotherapy #hematopoiesisandstemcells #transplantation

ABC and GCB subtype sinonasal DLBCL are geno- and phenotypically distinct entities, exhibiting a contrasting disease course and prognosis. ow.ly/lFOO50Rmt9n #lymphoidneoplasia

PI3Kγ/δ and NAMPT inhibitors synergize in blocking AKT activation and induce apoptosis, with potent antitumor activity in RS-PDX models. ow.ly/hKK250Rmt3U #lymphoidneoplasia

Low levels of BCR::ABL1 and deletions of B-cell development genes including IKZF1 and PAX5 are associated with tyrosine kinase resistance. ow.ly/Ohv650RmsXx #lymphoidneoplasia #clinicaltrialsandobservations