Conformationally sensitive nanobodies inhibit VWF binding of platelets by stabilizing the AIM conformation that masks the GPIbα-binding site. ow.ly/9HGJ50RGhre #thrombosisandhemostasis

Circulating multilymphoid progenitors are primed for the seeding the thymus and contribute to steady-state T-cell lymphopoiesis. ow.ly/Ftp950RASFI #hematopoiesisandstemcells

Targeting PI3Kγ represents a promising therapy that could improve outcomes and reduce toxicity compared to the current standard of care. ow.ly/rLPJ50RASpI #myeloidneoplasia #hematopoiesisandstemcells

Castleman disease with modest T-lymphoblastic proliferation
ow.ly/sx0350RARSg #bloodwork #lymphoidneoplasia

Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel
ow.ly/1ajH50RASCe #specialreport #lymphoidneoplasia

Taking AIM
ow.ly/t7x650RAShW #thrombosisandhemostasis

PIKing the right target in AML
ow.ly/6FWI50RAS1c #myeloidneoplasia

Transplant in AML: just follow the NPM1 guide!
ow.ly/lnLj50RARO5 #clinicaltrialsandobservations

SOX11 directly binds, via its HMG domain, to SAMHD1, reducing its tetramerization and inhibiting its ara-CTPase activity in MCL. ow.ly/yu3f50RASzp #lymphoidneoplasia

Adult-specific let-7 miRNAs inhibit the BCL11A repressor HIC2. ow.ly/29l250RAScE #redcellsironanderythropoiesis

Cryo-EM structure of the type I antiphospholipid antibody POmAb bound to the region R90-Y93 of kringle-1 of prothrombin is described. ow.ly/HwQu50RARX6 #thrombosisandhemostasis #immunobiologyandimmunotherapy

Unmasking atypical bone marrow TB
ow.ly/2Ov250RAQc9 #bloodwork #phagocytesgranulocytesandmyelopoiesis

Caplacizumab allows suspending PEX earlier, thus creating the impression that there is a delay in ADAMTS13 recovery after PEX end. ow.ly/JlV850RvWNt #clinicaltrialsandobservations #thrombosisandhemostasis

Novel risk loci for thrombotic factors
ow.ly/4tAZ50RvW4I #thrombosisandhemostasis

Silencing B3GNT2 and CD36 reduced factor VIII release in vitro. Silencing B3GNT2, CD36, and PDIA3 reduced von Willebrand factor release. ow.ly/Y8EB50RvVwu #thrombosisandhemostasis

T cells reinforce NK cell–mediated ADCC
ow.ly/U5Ph50Rv9LE #immunobiologyandimmunotherapy

How I treat long-term survivors of childhood acute leukemia
ow.ly/3iO350RvWIs #HowITreat #lymphoidneoplasia #myeloidneoplasia #pediatrichematology #transplantation

Using scRNAseq and Stereo-seq, IL-6 pathway signals were dominant in nodal fibroblastic reticular cells and endothelial cells. ow.ly/2ghV50RvVWP #lymphoidneoplasia

BCL2 inhibition: back to the future!
ow.ly/mLsb50RvVpp #lymphoidneoplasia