In a new Nature Chemical Biology study, Chris Parker and Teijaro Lab have developed an inhibitor for SLC15A4, a protein that was largely considered 'undruggable', offering hope against autoimmune diseases such as lupus and Crohn’s.

Read the full press release below: ow.ly/jBmA50QqbQt

Congrats to Chris Parker and team! Another great example of the power of chemoproteomics to discover small molecule inhibitors for challenging (membrane) proteins, this time a lysosomal one! Interesting that the small molecule inhibits protein-protein interactions (PPIs).

Excited to share the final version in
Nature Chemical Biology. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. nature.com/articles/s4158…

nature.com/articles/s4158… Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/ForliLab & Bristol Myers Squibb

Bravo! Congratulations to Belharra and its Scripps Research co-founders Chris Parker Teijaro Lab and Ben Cravatt!

Thrilled to share the first preprint from our lab on a expanded in vivo Perturb-seq platform, spearheaded by the very talented grad student Xinhe Zheng 💫 w close collaboration w Joshua Levin Sean Simmons Kwanho Kim (Broad) Xiangmin Xu (UC Irvine) -- check out the tweetorial!

Excited for this scripps Chem collaborative work out in nature w/Baran Lab & Lairson Lab. Has a bit of something for everyone…herculean total synthesis, structural reassignment, chemoproteomics, new druggable target, in-depth functional characterization & more

The Tetrahedron Prize Symposium is in room 7 at #ACSFall2023
Great talks so far from both Linda Hsieh Wilson Linda Hsieh-Wilson The Hsieh-Wilson Lab and Eric Jacobsen Jacobsen Lab celebrating our winner Chi-Huey Wong

Had the most wonderful time at #ACSFall2023 , full of fantastic talks! So inspiring to interact with some true #glycotime heroes!

“Ran” through my slides on the hotel treadmill one last time before tomorrow morning! Come check out an exciting session exploring the intersection of #glycotime and women’s health with me and some of my glyco-heroes! #ACSFall2023

I'm very excited to share my lab's discovery of a novel transcriptional regulator of heparan sulfate biosynthesis, now in press Journal of Biological Chemistry! Congratulations to amrita basu, Neil Patel, and the rest of the team!🧵👇 #glycotime #newPI
jbc.org/article/S0021-…

Surprising finding that the function of heparan sulfate, a polysaccharide critical for human development, depends not only on sequence but also localization Deena Al Mahbuba with Ed Boyden and Linhardt group from Massachusetts Institute of Technology (MIT) @RPI in ACS Nano #glycotime pubs.acs.org/doi/10.1021/ac…

This is an amazing honour - I am eternally grateful to all my mentors, my amazing lab members, colleagues Imperial Chemistry Imperial College London The Crick and the Biochemical Society! Glad to play a role in advancing #glycotime in biochemistry by using chemical tools...

Check out this new work from the Lairson Lab describing a small molecule prodrug targeting glioblastoma! Congrats Tommy West!

#glycotime

#glycotime

Congratulations to Jeffery W. Kelly, 2023 Wolf Prize laureate in Chemistry!
Scripps Research