Happy to share the publication of our paper in nature

Conformational ensembles of the human intrinsically disordered proteome

Work led by Giulio Tesei and Anna Ida🕊. I'll post more later, but for now here is a link:
nature.com/articles/s4158…
and a short movie about the work

Aquest 2023 ha sigut de somni✨

Tanquem la temporada + extraordinària dels Castellers de Sarrià

👉152 construccions descarregades
👉19 castells de 7️⃣
👉4 noves construccions
👉Un ambient insuperable

Hem escrit història, un any de superació i passió!

Com hi hem arribat?
Fil ⬇️

Still Open!!

I'm proud to introduce you to the IDRome 👋🍝

We performed simulations of 29,998 IDRs from the human proteome and analysed sequence-ensemble-function relationships.

For a quick intro watch 🎞️👇 and then read: biorxiv.org/content/10.110…

I'm pleased to announce the preliminary program for the 2024 Protein Folding Dynamics Gordon Research Conferences, to be held from 7-12 January 2024 in Galveston TX 🎡🌊🤠👢.
grc.org/protein-foldin…
We have a fantastic line up of speakers and discussion leaders! #PFD24

Excited to share our last work in bioRxiv, with RadfordLab, Antoine loquet, Jan Skov Pedersen, Daniel Otzen, JM Valpuesta, A Muga…
 
A bit closer to understand how #oligomers are!
 
A thread for all the #αsynuclein and oligomer enthusiasts! (1/7)

biorxiv.org/content/10.110…

All the academic and research tools that I shared in 2022!

A compilation of all 🧵’s

OpenAcademics The PhD Place #AcademicTwitter #scicomm

Very proud to see our latest work out. A super fun and creative collaboration with Rohit V. Pappu. Special thanks to first authors Kiersten Ruff and Yoon Hee Choi. protect-au.mimecast.com/s/syifCL7rxDsR…

The shape of things to come: structural insights into how prion proteins encipher heritable information. Excellent editorial by Glen Telling that neatly places recent Cryo-EM prion structure discoveries in the grand scheme of protein-based inheritance nature.com/articles/s4146…

Cryo-EM structures of α-synuclein filaments from Parkinson's disease and dementia with Lewy bodies | bioRxiv biorxiv.org/content/10.110…

Annovis Bio Announces Positive FDA Notice For Buntanetap Phase 3 Clinical Trial In Parkinson's Disease irpages2.eqs.com/websites/annov…

Here the link to the webpage article: nature.com/articles/s4225…

Protein folding from single sequences is enabled by replacing MSAs with protein language models! Amazing how rapidly this field has evolved since we started with LM-based 'contact prediction' in 2019 🚀

5 papers were published in this issue of Science about solving the jigsaw puzzle of the nuclear pore complex. Beautiful works and the cover!!!👏👏👏 The game is still on...🤓 science.org/doi/10.1126/sc…

Excited to share our story out in Nature Communications in collab. with Ed O'Brien's lab Penn State Chemistry led by the amazing Dan Nissley Oxford Statistics. We show that many E.coli proteins can misfold in subtle ways that would bypass the proteostasis network. Short 🧵
nature.com/articles/s4146…

ColabFold: making protein folding accessible to all | Nature Methods nature.com/articles/s4159…

Very interesting!!!

Frontiers | Genetic Variability of the Vitamin D Receptor Affects Susceptibility to Parkinson’s Disease and Dopaminergic Treatment Adverse Events | Aging Neuroscience frontiersin.org/articles/10.33…

We are back on Thursday with seminars by Sarah Bondos and Martin Blackledge Lab! Expect ensembles of disordered proteins by 💻 and 🧲!

New attendees sign-up at: idpseminars.com

Here's a quick preview of a ras signaling illustration I just completed, for use in an upcoming feature on structural biology of cancer at PDB-101 rcsb pdb 💉🧬💻🔬💊🌱🧠🦠. The folded portions are from the PDB archive, the wiggly bits are from AlphaFold2, all cobbled together in Photoshop.

An interesting event for 'biophysicists to-be' in the Barcelona area! Societat Catalana de Biologia
➡️iec.cat/jornades/biofi…