New Viewpoint JCellBiol: Stramer Stramer Lab and Sherwood Dave Sherwood discuss recent insight into basement membrane dynamics in live animals as well as considerations for the interpretation of fluorophore-tagged BM studies. hubs.la/Q02w9Gl30
#Development

In JGenPhysiol, Sebastian Duno-Miranda, Warshaw et al. University of Vermont investigate the E525K mutation in human β-cardiac myosin, a protein crucial for heart contraction, and its role in causing dilated cardiomyopathy (DCM). hubs.la/Q02wb1sF0

#CardiacMuscle #Contraction #CellMotility

In JCellBiol, Goto, Kimura et al. Tokyo Tech discovered histone H3K36me2, which is believed to be enriched in potentially active genomic regions, is also located in transcriptionally inactive regions called heterochromatin in some cell types. hubs.la/Q02w9KKm0

New Insights JExpMed: Adam J Rose and Sarah Lockie Monash University discuss new work by Tang et al (hubs.la/Q02w9SsT0) that describes how hepatic IRE1α-XBP1 signaling boosts GDF15-triggered appetite suppression and weight reduction in #chemotherapy . hubs.la/Q02w9yVD0

In JCellBiol, Melanie Krause Jason Mercer et al. UCL UoB Biosciences show that cytosolic replicating poxviruses disarm xenophagy during early infection by targeting a subset of #autophagy receptors required for pathogen detection hubs.la/Q02w9xPF0

#Virology

.JGenPhysiol's May issue is out! ➡️ hubs.la/Q02vLlGw0
On the cover image, steered molecular simulation captures the pre-powerstroke to post-powerstroke transition of cardiac myosin Loop-4 along cardiac actin. From Rynkiewicz et al. (hubs.la/Q02vLhtH0).

.JExpMed's May Issue is out! ➡️ hubs.la/Q02vLlg70
The cover shows a confocal image of mouse proximal colon with epithelial cells shown in blue. From Mohammad Arifuzzaman and colleagues (hubs.la/Q02vLhsP0).

.JCellBiol's May Issue is out! ➡️ hubs.la/Q02vLmCj0
The cover shows STED microscopy image of myosin IIA (green) and ZO-1 (magenta) of claudin/JAM-A KO MDCK II cells. From Thanh Phuong NGUYEN (tann), Tetsuhisa Otani et al. (hubs.la/Q02vLhrT0)

Spotlight in JCellBiol: Kawauchi and Ito Kyoto University discuss recent work from Dayoung Kim et al. (hubs.la/Q02w1krD0) on how pediatric #glioma cells migrate on neurons, astrocytes, and the extracellular matrix. hubs.la/Q02w1wNK0

In JExpMed, Tang, Yao et al. demonstrate that hepatic IRE1α acts as a molecular driver of GDF15-mediated anorexia, and blocking IRE1α activity offers a potential therapeutic approach to alleviate anorexia in #chemotherapy . hubs.la/Q02vS_V50

#Metabolism

In JCellBiol, Pinto, Bessis et al. IBENS show that microglia regulate the daily plasticity of inhibitory synapses by promoting the synaptic enrichment of GABAᴀR in the light/sleep phase. hubs.la/Q02vS_yF0

Exciting news! JExpMed's Academic Editors Susan Kaech (@Tcellogic) Salk Institute and Anne O'Garra The Crick have been elected to the National Academy of Sciences National Academy of Sciences! Congratulations on their achievements 🎉 hubs.la/Q02vMz9B0

Are you attending #IMMUNOLOGY2024 #AAI2024 this weekend in Chicago? Stop by JExpMed booth #649 to chat about the journal, and pick up a copy of JEM Immunology Collection magazine 📚 and an exclusive zip-up pouch 🎁
We look forward to seeing everyone!

.JCellBiol is proud to share a collection of #immunology papers that most interested our readers over the past year. Explore new research on host-virus interactions, T cell development and activation, myeloid cells, B cells & more: hubs.la/Q02vx_TJ0
#AAI2024

.JExpMed is proud to present a special collection of recent and exciting advances in #immunology , celebrating JEM’s long commitment to publishing outstanding basic, as well as translational, studies ➡️ hubs.la/Q02vxXt70
#AAI2024

New Review in JCellBiol: Kaji lab, Thiagarajah Lab and Goldenring Lab Vanderbilt Health discuss recent findings in cell, organoid, and animal models for monogenic diseases causing congenital diarrhea and enteropathies (CODEs). hubs.la/Q02vmxM80

#Disease #Physiology #Trafficking

In JCellBiol, Scott, Roux et al. Sanford Research show that changes in the availability of cellular GTP resulting from physiologically relevant processes, incl. cell migration & cell spreading, alter the rates of Ran-dependent nuclear import and export. hubs.la/Q02vmC2p0

Happy International #DayOfImmunology ! JEM’s Gaia Trincucci speaks with Dr. Arlene Sharpe Harvard Medical School & Dr. Kristen Pauken MD Anderson Cancer Center who share their stories as immunologists and insights into career paths as #WomeninSTEM . Full interview here ▶️ hubs.la/Q02vkV8K0

Going steady for maturity: a subset of CD63-rich #endosomes partner w/ #microtubule -associated #septins , which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New JCellBiol by Elias Spiliotis Drexel University College of Arts and Sciences UVa Cell Biology: hubs.la/Q02v9QqQ0

New Review JExpMed: Loffredo, Savage, Ringham, and Arpaia The Arpaia Lab Microbiology & Immunology at Columbia University examine the interactions between Treg cells and tissue-specific non-immune cells that mediate repair and #regeneration following sterile or infectious damage. hubs.la/Q02v9Mys0

#StemCells