Patterns of cardiac damage secondary to aortic stenosis differ by sex. Female sex was an independent predictor of lower mortality in early stages, but not in advanced stages of upstream cardiac damage. authors.elsevier.com/sd/article/S19…
Masaaki Nakase Daijiro Tomii Fabien Praz Annette Maznyczka

Medical News in Brief: Climbers at High Altitudes at Risk of Heart Rhythm Abnormalities ja.ma/3wcCoBn

Cardiac damage staging in aortic stenosis is ready for prime time. Excellent Editorial by Philippe Pibarot. sciencedirect.com/science/articl… Masaaki Nakase Daijiro Tomii Fabien Praz

Prediction of the Individual Aortic Stenosis Progression Rate and its Association With Clinical Outcomes jacc.org/doi/10.1016/j.…

The extent of extra-valvular cardiac damage before and after TAVR and changes in cardiac damage early after TAVR have important implications during long-term follow-up.
authors.elsevier.com/a/1izXK6uPJvuU…
Masaaki Nakase; Daijiro Tomii; Fabien Praz; Stefan Stortecky

In the SUMMIT study, we found a substantial incidence of cardiac arrhythmias among climbers on Mount Everest. Next, we will dive deeper into the pathomechanisms and try to identify individuals at increased risk of serious adverse events.
jamanetwork.com/journals/jamac…?

More than one in three climbers experienced cardiac arrhythmias during the ascent from base camp to the summit of Mount Everest. Find out more about the SUMMIT study JAMA Cardiology jamanetwork.com/journals/jamac…? Everest Today Stephanie Geiger Amy Woodyatt Alan Arnette Angela Benavides

A look behind the scenes of the SUMMIT study
swisspolar.ch/2023/12/latent…

The management of combined AS and MR is challenging due to hemodynamic interdependency. Transcatheter treatment modalities allow for tailored timing of intervention with re-assessment of concomitant valvular lesions and potential staged interventions. sciencedirect.com/science/articl…

In an analysis of 21 high-income countries, TAVI numbers tripled between 2014 and 2019. Countries with a greater adoption of TAVI had a lower age-adjusted mortality due to aortic stenosis in elderly individuals. ahajournals.org/doi/10.1161/CI…

Expansion of Transcatheter Aortic Valve Implantation and Mortality due to Aortic Stenosis Between 2010 and 2019 ahajournals.org/doi/10.1161/CI…

In patients undergoing primary PCI for STEMI, biodegradable polymer SES were superior to durable polymer EES with respect to TLF at 5 years. The difference emerged within the first 2 years and was driven by TLR. authors.elsevier.com/c/1h~IdV-4XL5cR

Pulmonary ViV implantation with a doubly folded Melody TPV for safe anchoring in a large bioprosthesis

In Bern, Switzerland, TAVI during COVID-19 surge periods was associated with higher STS-PROM score, longer wait times, and increased 30-day mortality compared with non-surge and pre-pandemic periods. authors.elsevier.com/sd/article/S00…

Atrial fibrillation is prevalent among patients with low-flow low-gradient aortic stenosis with preserved LVEF, and associated with poor recovery of stroke volume after TAVI and adverse clinical outcome. academic.oup.com/ehjqcco/articl…

In the SCOPE I trial, early differences between Acurate NEO and Edwards SAPIEN S3 #TAVI did not translate into significant differences in clinical outcomes or bioprosthetic valve failure throughout 3 years. ahajournals.org/doi/10.1161/CI…

Harsh weather conditions stalled our #Everest expedition on the South Col at 7900 m. But the journey continues, stay tuned for the summit-study.org.

Sunset in camp 2
#Everest

Pre-procedural CT-workup for TAVI exposed previously undetected malignancy in 4.5% of patients. TAVI patients with incidental malignancy had a 2.9-fold increased risk of death at 1 year, and a 16 months shorter mean survival time. doi.org/10.1016/j.ahj.…

In a 1:1 propensity-matched analysis the echocardiographic hemodynamic advantage of self-expanding THVs was not associated with better clinical outcomes compared with balloon-expandable THVs up to 5 years in patients with small annuli. jacc.org/doi/10.1016/j.…