Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/

nature.com/articles/s4158…

1/ We are extremely excited to share our new manuscript published Cancer Cell! Kudos to co-first authors Avishay Spitzer, MD, PhD 🎗️💔, Simon Gritsch and Masashi Nomura for seminal work, to co-PIs Mario Suva, Dan P. Cahill and Keith Ligon and to all contributors.

OK, this one is really meaningful for our whole team. Our preclinical paper on pan-RAS inhibition in pancreatic cancer is now online nature. Led by OliveLab student Ula Waśko and Revolution Medicines colleagues JingJing Jiang and Mallika Singh. nature.com/articles/s4158…

The first paper from the Phipson lab has been published today in Genome Biology! Very proud to share this work, led by the talented Givanna Putri. SuperCellCyto: efficient analysis of cytometry data. A quick summary follows.
genomebiology.biomedcentral.com/articles/10.11…

We are hiring and would ❤️ to meet you! careers.gene.com/CFYb9di New PhDs and post-docs are highly encouraged to apply. Great opportunity for candidates with a strong background in computational immunology to collaborate with awesome TurleyLab .

What is the role of the TME in lung cancer evolution? We are excited to share our new TRACERx paper “Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer” at #AACR24 , out in Cancer Discovery today rb.gy/q484j9 Tweetorial👇

Desde la red de científicos argentinos en Suiza invitamos a todos nuestros miembros a colaborar cafecitos para este maravilloso festival de la ciencia! 🧬🇦🇷

Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis science.org/doi/10.1126/sc…

In their Specious Art paper, Chari & Lior Pachter claim that tSNE/UMAP are as arbitrary as a random elephant shape. But are they?

We show in our comment that this is false and throws the tSNE/UMAP baby out with the bathwater!

Details in 🧵& paper:

biorxiv.org/content/10.110…

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Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk disq.us/t/4nqs6ky

Great and inspiring writing advice, for any type of grant application, though naturally focused on NIH.

Elements of successful NIH grant applications | PNAS pnas.org/doi/10.1073/pn…

The covariance environment defines cellular niches for spatial inference go.nature.com/4auQI72

Very happy to see our pre-print out! High-resolution scRNA-seq sheds light on the genomic determinants of antigen switching hierarchy in African Trypanosomes! It's been a journey filled with perseverance, but it's paid off! Huge congratulations to the entire team! 🎉 Take a look!

If you have immunology expertise & a desire to review papers then please reach out to me, & I'll add you to our list for Discovery Immunology Journal

I think more junior people are often closer to the nitty gritty of experiments, so can offer insights that many senior people can't. My email.

We are hiring!
We are looking for a bioinformatician with skills in designing and analyzing -omics data, for a 3-years position in our facility supporting the Department of Biomedicine and Biozentrum at the University of Basel. jobs.unibas.ch/offene-stellen…

Super excited to share our work on #celiac disease. We discovered T cells carrying somatic mutations which may explain chronic autoimmune disease
medrxiv.org/content/10.110… . Great team work led by Manu Singh. Thank you to all authors!

Great study with important insights into fundamental T cell biology. Congrats Will Bailis and team! 🥳