O Laboratório Intermediário de Neuropatologia Experimental tem uma vaga para pós-doutorado com bolsa em um estudo em modelos experimentais de AVE. Interessados podem entrar em contato via DM ou email.

My home state was devastated by unprecedented floods. Thousands of people do not have food, water or shelter. Our entire state will have to be rebuilt. Your support can make a real difference in the lives of those affected vakinha.com.br/4712837

It breaks my heart to see the place I call home suffering like this!

Many people lost their homes, if you would like to help you can donate via the link below:

vakinha.com.br/4712837

Brain changes associated with AD can begin up to 20 yrs or more before the onset of symptoms. Quesnel et al. find that IGFBP2 may be a valuable marker for identifying at-risk individuals and could serve as a target to restore deficient insulin signalling. tinyurl.com/mu39ybvy

We need international support. My state (RS, Brazil) is facing the worst climate disaster in its history. Millions of people are displaced, without water, food including friends and family members. Please donate, the money will reach those who need more. Help us spread the world

Doem, se possível. Porto Alegre precisa bastante de ajuda. Alguns colegas, como o Felipe Ricachenevsky, estão diretamente recebendo doações para ajudar quem precisa. O Felipe Ricachenevsky é professor universitário e cientista e confiável.

Porto Alegre (a town in southern Brazil) is flooded and many people lost everything they had. Many with no plain water or food. If you will, please donate any value you can.

Bank account – 2622 0006 000000071336-1
SWIFT – CEFXBRSP
IBAN – BR48 0036 0305 0282 2000 0713 361C1

People with 2 copies of APOE4 were known to have a high risk of #Alzheimers .
Today that changed to nearly 100% full penetrance
NATURE.med
nature.com/articles/s4159…

Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation dlvr.it/T6VDC5

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease

Published last week at Lancet Neurology.

The main finding was that at similar levels of amyloid pathology, people with Down syndrome had greater tau load compared with people…

When does Alzheimer’s disease start?
(i.e., their provocative title, not mine)

Recent preprint at Lancet Neurology

The main results of this large-scale analysis across 3 cohorts (n=1,088 w/4,383 Amyloid PET scans):

1⃣ There is a time window of ~16.5 years between crossing the…

➡️ International Society for Neurochemistry (ISN) owned and community led
➡️ Dedicated Editorial Office
➡️ Diverse, international Editorial Board
➡️ Initiatives to support our next generation of young scientists

That's Journal of Neurochemistry!

Temporal dynamics of the multi-omic response to endurance exercise training | Nature nature.com/articles/s4158…

New publication alert!📢In the latest work from our group 👇 we've shown that microglia has the highest senescence burden in Alzheimer's disease which positively correlates with beta-amyloid load. Check it out here:
link.springer.com/article/10.100…

Finger-prick blood testing🩸shows promise to help traumatic brain injury / Alzheimer's diagnosis, as this remarkable technology continues to improve.
Wonderful working with Nicholas Ashton Magda Mike Hanna Henrik Paresh Malhotra @Neurosharp & more on it: academic.oup.com/braincomms/adv…

Lewy body pathology is found in ~50% of both sporadic and familial Alzheimer's disease. Levin et al. showed that:

1. 0/26 of asymptomatic and 3/27 (11%) of symptomatic AD mutation carriers tested positive on an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid.…

Excited to share the pre-print of our latest work on the AD resilience mutation Christchurch, elucidating a central role of cGAS-STING and IFN suppression! Congrats to first authors Sarah Naguib, PhD Eileen Torres, Ph.D. Chloe Lopez-Lee, Ph.D. biorxiv.org/content/10.110…

An interesting work by Joseph Therriault Andrea L. Benedet as eBioMedicine – The Lancet Discovery Science editor pick. Kudos to this great team!

We are hiring! Come join the Scientific Conference Programming team of the Alzheimer’s Association!

The Specialist is in charge of the planning, logistics and execution of AAIC and our other scientific meetings.

Alzheimer's Association ISTAART

jobs.alz.org/specialist-sci…

Join us in Brazil for hands-on training in #SingleCell genomics & #bioinformatics ! 🇧🇷

Apply for a FREE place to #SingleCell Rio24 by 7 May⏰
Click▶️bit.ly/3J3Wu3D 

This is a tailored training course for scientists working on research questions for #LatAM populations.