The HACKD score was devised as a simple tool to predict the rate of GTR in pituitary adenomas,
based on factors in the image and demonstrated excellent discriminative ability (AUROC = 0.89).
Take a read

journals.lww.com/onsonline/abst…

Can the Shield blood test improve #ColorectalCancer screening rates despite its low sensitivity for advanced adenomas? U.S. FDA weighs in.
bit.ly/4e2FmcL

The promise of -omics biomarkers. Interesting talk from Graeme Eisenhofer on mass spec plasma steroidomics, 18-oxocortisol in KCNJ5-mutated adenomas. #IFCC #WorldLab IFCC&LM

Mainz Biomed $MYNZ +36% 🚀🚀🚀
Exact Sciences Corp $EXAS -24.4% 📉⬇

MYNZ's 82% sensitivity for advanced adenomas significantly surpasses Cologuard's 43%. This early detection advantage is crucial and may justify the selloff in EXAS.

🌟 Exciting update! $MYNZ is set to present findings from the eAArly DETECT study at Digestive Disease Week 2024 in Washington, D.C., showing 97% sensitivity for CRC and 82% for advanced adenomas, using a combination of FIT, DNA, and mRNA biomarkers, enhanced by AI. #DDW2024

It's just pseudo-invasion (epithelial misplacement) in an adenoma, but the hemosiderin deposition is striking. Curiously, mostly non-neoplastic mucosa has prolapsed into the submucosa since adenomas have 'top-down' growth. #UMiamiPath

Conventional Adenomas of the Colon

▪️Tubular adenoma
▪️Tubulovillous adenoma
▪️Villous adenoma

🔬% tubule component
🔬% villous component
🔬ALL have dysplasia present!

NOTE: reliability of dysplasia has high pathologist inter-observer variability!

🔗 pubmed.ncbi.nlm.nih.gov/28396276/

#CoMICWednesday
#EJECoMICs Ep 46: NEW Euro J Endocrinology paper: Comparative Analysis of Intraoperative and Imaging Features of Invasive Growth in Pituitary Adenomas

Watch 👉 youtu.be/NnzcSx2ogS0
Full paper 👉 doi.org/10.1093/ejendo…

By CoMICs led by Josh ESE_President

Adenomas of the ___-type show expression of ___ mucin(s)
a) intestinal
b) foveolar
c) pyloric
d) oxyntic
#GIPath #PathTwitter #Pathology

Pituitary Adenoma
ورم الغدة النخامية
من الاسئلة المهمة للدراسات العليا
كيف نفرق بين
Macroadenomas and Microadenomas?

Adenomas that measure less than 10 mm are defined as microadenomas, while those measuring greater than 10 mm are defined as macroadenomas.

Images(macroadenomas)

Multiple ___ is a major diagnostic criterion for ___ Syndrome
A) Cylindromas
B) Trichilemmomas
C) Sebaceous adenomas
D) Basal cell carcinomas
#pathtwitter #bstpath #dermpath #pedipath

“Pleomorphic Adenomas” are often quite “cellular” and stroma can be exceedingly difficult to appreciate on Pap stain (not a reason to call them “atypical”). Parotid FNA

With years of research and development endoscopy equipment has gone from fiber optic to ultra-high magnification endoscopes with artificial intelligence (AI). It allows endoscopists to detect polyps, especially adenomas at the earliest possible stages. Which leads to a

💢Our article in Acta Neurochirurgica

📌Clinical presentation and surgical outcomes of very large and giant pituitary adenomas: 80 cases in a cohort study of 306 patients with pituitary adenomas

👉Giant PA have <resection rates and >postQx complications
link.springer.com/article/10.100…

Spoiled: back-to-back NEJM studies on colorectal cancer screening❗️

Although comparing across studies, my summary below suggests:
➡️Next Gen STOOL DNA has much higher sensitivity for CRC and advanced adenomas than cell-free DNA BLOOD TEST at same specificity.

We are proud to announce that Dr. Aditi Kumar, our renowned Pituitary Endocrinologist, will be part of the Boulders 2024 faculty. On April 6th, join us for the Tumor and Skull Base Session to learn more about the Medical Management of Pituitary Adenomas. Register today at

Pleomorphic Adenoma of the lower eyelid misdiagnosed as recurrent chalazion. Most of the pleomorphic adenomas arise from the lacrimal gland or the upper eyelid. #eyetwitter ow.ly/uzL150QK5ag

Glad I stayed till the end to listen to NickSchieda's excellent talk on adrenal incidentalomas.

Highlighting:
1️⃣the (extremely) high pretest probability of being adenomas
2️⃣pitfalls of CT (unenhanced and adrenal washout)
3️⃣'If' you decide to do imaging, MRI>adrenal washout CT

Permission from Sarah to share this image of 2 adenomas removed by SK Oxford. Both ultrasound & nuclear scans only showed superior left. I'd like every scan guided #parathyroid surgeon to read this & consider outcomes for their own patients. This is a common finding.

Congrats to amazing JHU med student Melanie Alfonzo Horowitz on an amazing podium presentation (top abstract) on her important work on Air Pollution and Pituitary Adenomas at the MSRS! ⁦Johns Hopkins OHNS⁩ ⁦Johns Hopkins Medicine⁩ ⁦Johns Hopkins Neurosurgery⁩ ⁦Johns Hopkins Neuro-Oncology Surgical Outcomes Lab⁩