Check out Editor’s Picks like “Distinct local and global functions of mouse A? low-threshold mechanoreceptors in mechanical nociception” on #PRF #PapersoftheWeek bit.ly/3Ub4qGy

New data from a controlled study presented at #WCA2024 showed that #NOL -guided analgesia in radical prostatectomy surgeries led to 20% reduction in intraoperative remifentanil use + lower pain scores up to 3 days postop. Reach out to learn more about NOL nociception monitoring.

John Bockmann I do agree with Dr Anand that's there's a lot of conceptual sloppiness between nociception and pain.
Others have noted the same.
sciencedirect.com/science/articl…
jpain.org/article/S1526-…

MissAnthrope '...what was denied was [not just infant pain but] the detrimental effect of nociception.'

Sorry, but that's roughly the opposite of what Anand's passage says. Anand proposes nociception because it's important and everyone can agree on it.

Interesting that he still calls it…

The Periaqueductal Grey matter. A key component of nociception and affective behavior. The authors analyze the connectivity and propose a subdivision of PAG, as follows: dorsomedial, dorsolateral, lateral and ventrolateral. 👇🏼

fascinating illusion training used to 'prove' that nociception can occur in absence of injury.

Did you know that insects might experience pain? Recent research suggests they're not just mindless automatons. 🧠🦗

Evidence Points to Sentience:
- Nociception, their version of sensing unpleasant stimuli, triggers physiological and behavioral responses.

Check out Editor’s Picks like “Distinct local and global functions of mouse A? low-threshold mechanoreceptors in mechanical nociception” on #PRF #PapersoftheWeek bit.ly/3Ub4qGy

Research summary: The evolution of nociception in arthropods — Effective Altruism Forum
forum.effectivealtruism.org/posts/AuJHSEvH…

John Bockmann Now of course they have markers, some of which loosely correlate with nociception, some that don't.
They can't use EEG or NIRS routinely-it's not valid on its own anyway. That's not how pain works.
But we can't ask so we need better measures
Brain+behavior
doi.org/10.1016/j.siny…

John Bockmann Re nociception
doi.org/10.1016/j.neur…
Or read the paper.
Or don't. It's all up to you.
twitter.com/LyssAnthrope/s…

John Bockmann Anand: '...terms relating to pain and nociception are used interchangeably; in this review, no further distinction between the two will generally be made.'

IASP: 'Pain and nociception are different phenomena'
nejm.org/doi/10.1056/NE…
ncbi.nlm.nih.gov/pmc/articles/P…

'silent darkness, concealing a heart in nociception.'

John Bockmann NICU staff report difficulty with assessing pain based on behavioural and physiological indicators.
And responses can be the same for noxious and innocuous stimuli
Ex.
jpain.org/article/S1526-…
We don't generally treat pain. Most tools measure nociception and pain is untreated.

John Bockmann 'The focus on pain perception in neonates..differentiation from nociceptive activity and..accompanying physiologic responses..obscured...that nociception is important..regardless of any philosophical view on consciousness and 'pain perception' in newborns'
twitter.com/LyssAnthrope/s…

Reveri Tim Ferriss Thanks, I really appreciated your simple but profound description of pain. Many pain neuroscience experts eg Mosely deny the fact you need nociception to feel pain - they are obsessed with the salience part. Bud Craig’s work on interoception and pain is a game changer !

John Bockmann Oh no, they didn't just deny pain.
Historically what was denied wás the detrimental effect of nociception.
That's what Dr. Anand was talking about in his seminal work on neonatal pain.
This paper right here:
twitter.com/LyssAnthrope/s…

The Insect Brain Mystery:
- Insects likely have central nervous control over nociception.
- Could they perceive pain? 🤯
- Scientists debate whether their experience aligns with ours.

If insects feel pain, how should we treat them in labs and the wild?

MissAnthrope How do you know most tools measure nociception?

Read Editor’s Picks on #PRF #PapersoftheWeek : Distinct local and global functions of mouse A? low-threshold mechanoreceptors in mechanical nociception bit.ly/3Ub4qGy