Screening for fibrosis promote life-style changes
 
4,796 at risk of ALD or MASLD- 6 months and 2 years
👉ALD excessive drinking decreased from 46% to 32%
👉MASLD 35% diet ⬆️, 22% exercised⬆️, 13% weight loss ≥5%
👉impact partly lasted after 2 years
cghjournal.org/article/S1542-… 🔓

🆕Article in press❕

Post-treatment LSM rather than change during treatment predicts decompensation in patients with cACLD after HCV cure

🔓 #OpenAccess at👉journal-of-hepatology.eu/article/S0168-…

#LiverTwitter

Check out our new paper on sarcopenia🏋🏻
📌 39 studies and >10.000 patients
📈 Higher mortality, but do we do define sarcopenia?
✅ Confirmed prognostic impact of SMI and EASL/AASLD cut-offs
❓Role of psoas muscle, definitions too heterogeneous to be validated
JHEP Reports

📑 Are there responders and non-responders to beta-blockers⁉️

This systematic review shows:
1️⃣ Homogeneous patient-by-patient response and
2️⃣ suggests routine portal pressure measurements may not be needed to guide beta-blocker use❕
#LiverTwitter

journals.lww.com/hepcomm/fullte…

HBV antivirals prevent HCC.

What % of pts with HBV get an adequate evaluation to assess treatment eligibility based on AASLD criteria?

What % receive treatment?

👩‍🦰 disadvantaged!

We evaluated 🔼 in 25 centers/>12K pts

Journal of Hepatology

free link:
authors.elsevier.com/a/1j0lccOnAUb9O

NEW PAPER out today in @BMJ_latest TRIPOD+AI: reporting recommendations for studies developing or validating prediction models for use in healthcare that use #machinelearning methods

bmj.com/content/385/bm…

#ArtificialIntelligence #AIstandards #OpenAccess

Please share 🙏

Read open access 'Branched-chain amino acid supplementation does not improve measures of sarcopenia in cirrhosis: results of a randomised controlled trial' at bit.ly/3uNXHZn
#livertwitter #cirrhosis #clinicaltrial

How can we identify MASH resolution without a liver biopsy? New data NAFLD ResearchCenter Gut Journal Rohit Loomba

➡️ The MASH Resolution Index

➡️ Comprises ALT, AST, MRI-PDFF

➡️ Another step towards a biopsy free world?

#LiverTwitter

gut.bmj.com/content/early/…
gut.bmj.com/content/early/…

🤩We summarized the existing pharmacological therapies for #portalhtn in #cirrhosis Juan G Abraldes

🗝️Etiological tx
✅NSBB
✅Vasoactive agents
✅Statin & metformin

In Press here: shorturl.at/iGKRW

#Livertwitter #GITwitter #MedTwitter #medstudenttwitter

'Long-term clinical outcomes in steatotic liver disease and incidence of liver-related events, cardiovascular events and all-cause mortality' now published at
bit.ly/3xTOJLh
#SLD #Livertwitter #MASLD #MetALD

Elliot Tapper great thought: paths after #decomensation
😫 further decompensate: t.ly/4-nGZ
🙃 control symptoms by etiolologic ther
🛑🍻alcohol abstinence t.ly/o0Qxd
🛑🎊viral eradication t.ly/uXV46
✅ fully recompensate (Alb, INR) t.ly/7Y4T5

Further decompensation as a new advanced stage of cirrhosis is making the rounds in recent papers

here me out, #livertwitter

Further REcompensation!

No more ascites? Recompensation
Albumin from 3.0➡️4.3? Further REcompensation

Only no papers. Just celebratory portal messages

Compared to ascites, hepatic HYDROTHORAX:

- Poor response to diuretics, >AKI and HipoNa.
- Repeated thoracocentesis is hard: consider TIPS.
-Increased mortality with lower MELD.

This study in HEPATOLOGY Journal shows its poor prognosis.

#LiverTwitter
tinyurl.com/4jfs4ce7

Nice study with very needed data regarding the risks when patient has reversion from cACLD (cirrhosis) to non cirrhotic state (F3 or less).

Even though we predict minimal/ no risk of decompensation o CSPH , we still unsure of the need for HCC surveillance
Liver Fellow Network EASLnews

When repeat LSM drop below 10kPa (🌟'Resolved-cACLD):

✅No decompensation/liver-related☠️
‼️HCC risk remained -> surveillance needed
✅~30% of cACLD
👀Who: Caucasian, non-DM, lower prior LSM, >LSM reduction

New Pub👉shorturl.at/tENU8

#Livertwitter #Gitwitter Elliot Tapper

AFRI-SWE for cACLD setting:

✅SWE has prognostic value, but ‼️ cutoff is DIFFERENT from VCTE

👉youtu.be/yqlfhEXoQSQ

#Livertwitter Thomas Reiberger Annalisa Berzigotti Juan G Abraldes Elliot Tapper