A real tour d’horizon on chronic neutrophilic leukemia by Natasha Szuber
#mpnsm #cnl #leuksm AmericanJournalofHematology Vincent Rajkumar
American Journal of Hematology | Blood Research Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/aj…

I love this figure from a recent review of high risk MM by Matthew Rees and Shaji Kumar in AmericanJournalofHematology. Risk is a spectrum that involves so much more than cytogenetics and ISS stage! #mmsm

onlinelibrary.wiley.com/doi/full/10.10…

Not all lymphomas are created equal: Different histology types pose unique #thrombosis risks. We developed and validated a #VTE risk assessment model in #lymphoma patients across 3 diverse cohorts: doi.org/10.1002/ajh.27…
Calculate VTE risk online:
dynamicapp.shinyapps.io/Lymph-CAT/

Please also check out the recently released Chronic myelomonocytic #leukemia : 2024 update on Dx, risk stratification and management from Drs. Mrinal Patnaik & Ayalew Tefferi
Including #CMML clonal evolution & unique associations
Free access: doi.org/10.1002/ajh.27…
#hemepath

Myeloid neoplasm with <10% blasts and t(3;5)(q25.1;q34)/NPM::MLF1: A classification dilemma
Images in #Hematology from Dr. Sanam Loghavi, MD صنم لغوی 🔬🧬 and colleagues, now free to access online!
onlinelibrary.wiley.com/doi/epdf/10.10…

The CLL2-BCG-trial by the German #CLL Study Group confirms the known severe toxicities of idelalisib and advise bendamustine followed by idelalisib and obinutuzumab should only be used with caution and if all other treatment options are exhausted onlinelibrary.wiley.com/doi/pdf/10.100… #lymsm

Phlebotomy is a controversial but effective treatment for chronic mountain sickness (CMS). CMS blood is usually discarded, but a new study finds no differences in the properties of red blood cells from CMS patients compared to healthy controls
doi.org/10.1002/ajh.27…
#transfusion

Hairy cell #leukemia 2024: Update on diagnosis, risk-stratification and treatment
Including Dx & treatment algorithms and guide to cytologic features of HCL, HCL variant, splenic MZL & splenic diffuse red pulp #lymphoma !
Free access now: doi.org/10.1002/ajh.27…
#hemepath #HemOnc

Please check out the special issue on Hemostasis Management in Female Patients with Guest Editor Prof. Professor Beverley Hunt OBE!
The collection includes this excellent article by Julia R Coleman, MD MPH et al. on Sex dimorphisms in #coagulation relevant for #trauma management doi.org/10.1002/ajh.27…

In NDMM, how does KRd compare to VRd regarding efficacy endpoints? Happy to share our new meta-analysis just published in AmericanJournalofHematology: doi.org/10.1002/ajh.27….

KRd-treated pts showed higher odds of achieving MRD negativity and CR/sCR compared to VRd-treated pts, while ORR,

Finally out in AmericanJournalofHematology!
In adults with :
1⃣hypereosinophilic syndromes AND
2⃣“myeloid” features (splenomegaly, ⇑ tryptase, other CBC abnormality, corticoR) AND
3⃣lacking tyrosine kinase fusions
👉>50 % have mutations in the JAK-STAT pathway
#MDSsm #MPNsm #leusm #CEREO

One of our top ten articles this month: Sairah Ahmed MD et al in AmericanJournalofHematology: Eltrombopag improves platelet engraftment after haploidentical bone marrow transplantation
stemcellevidence.com/alerts/article…
#BMT #StemCellEvidence

Excited to share our review published in AmericanJournalofHematology on sex dimorphisms in coagulation & the impact of female-specific hypercoagulability on resuscitation of bleeding patients Gumina Lab Matthew D. Neal, MD Mitchell Jay Cohen Dr. K (Bryce Kerlin, MD) Dr Kristy Townsend Ohio State Wexner Medical Center Surgery Dept. onlinelibrary.wiley.com/doi/10.1002/aj…

Julia R Coleman, MD MPH AmericanJournalofHematology Gumina Lab Matthew D. Neal, MD Mitchell Jay Cohen Dr. K (Bryce Kerlin, MD) Dr Kristy Townsend Ohio State Wexner Medical Center Surgery Dept. 👏Wonderful review!. The causes , mechanisms of female specific hypercoagulability are elegantly explained + impact on resuscitation of patients’ with trauma induced coagulopathy👏

Our two institution (UAB and Mayo Clinic) experience for an ultra-rare disease, malignant histiocytosis, encompassing the 'sarcomas' (histiocytic, dendritic and Langerhans). Kudos to Gordon Ruan, MD for his perseverance on this study that took nearly 5 years to publish.Histiocytosis Assoc

World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management
Now online & free access! doi.org/10.1002/ajh.27…
#hemepath #hematology #mpnsm #eosinophilia

World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management AmericanJournalofHematology
onlinelibrary.wiley.com/doi/10.1002/aj…

This was a monumental lession in patience that I learned from my dear friend Gordon Ruan, MD! We first spoke about this on a bus ride to McCormick place when this was presented at ASCO in 2019! ‘Slow’ forward 5 yrs, your dedication to pts with a rare disease helped get this data out

Repeated doses of haploidentical expanded NK cell therapy were safe & well-tolerated without infusion adverse effects.
~60% of patients with refractory #AML achieved remission after administration of multiple doses of ex vivo expanded NK-cells #celltherapy
doi.org/10.1002/ajh.27…

A randomized comparison between KTd and KRd therapy in 123 elderly #myeloma patients showed similar activity but a different tolerability profile.
A second randomization showed no advantage for maintenance therapy with carfilzomib doi.org/10.1002/ajh.27… #MyelomaActionMonth