« TIME» is the theme of this morning session with another beautiful lecture by IdoAmitLab describing a new technology (zmanseq) he developed to capture the dynamic molecular programs acquired by macrophages at different time during tumor progression - #KSMyeloidTargets24

We start the day with superb talks from Julie Helft Julie Helft and Jennifer Guerriero Jennifer Guerriero, PhD on TAM heterogeneity and the effect of treatment on macrophage activation in vivo. Also new Macrophage-targeting clinical trial being launched 👏🏻👏🏻👏🏻 #KSMyeloidTargets24

With associated Figure ! Bravo again for a beautiful lecture @realFlorentGinhoux

Excellent lecture by @realFlorentGinhoux describing a novel conditional fate mapping model of monocytes in pancreatic tumors - enabling to capture the spatiotemporal molecular states acquired by monocytes at different time during tumor progression - Beautiful ! #KSMyeloidTargets24

Tour de force keynote lecture by Martin Guilliams #KSMyeloidTargets24 describing the building blocks in tissue and cellular circuitries that control tissue integrity and the key role of tissue resident macrophages within these blocks - Thank you for the great lecture

🤯🤯🤯 What a morning session with brand new data of Philippe Benaroch Institut Curie designing CAR-macrophages, IdoAmitLab on new macrophage CRISP-seq data and @realFlorentGinhoux on time-stamping to understand lineage & origin of tumor-macrophages. Time, space and origin matters!

🔍📰New #review in Cancer Cell by Dr. Direna Alonso-Curbelo- #IRBBarcelona , Dr. @realFlorentGinhoux-Gustave Roussy et al:

📜'A temporal perspective for tumor-associated #macrophage identities & functions'

➡️shorturl.at/yNRS9

📌doi.org/10.1016/j.ccel…

#CancerResearch #Immunology #Inflammation

Fantastic talk of Miriam Merad, MD, PhD #KSMyeloidTargets24 🤩🤩🤩. Particularly excited by wiring of myeloid precursors in the bone-marrow and imprinting of an IL4R program. Super excited to see promising results of IL4-receptor blockade together with anti-PD1 in cancer patients! 👏🏻👏🏻👏🏻

t- 3 days until I give the Cogan lecture. Slide deck complete but still feeling anxious! #arvo2024

adding here the studies showing that Langerhans cells and macrophages are maintained independent of adult hematopoiesis : ncbi.nlm.nih.gov/pmc/articles/P…; ncbi.nlm.nih.gov/pmc/articles/P…

This provides another beautiful proof that macrophages including Langerhans cells develop independently of adult hematopoiesis as we showed more than a decade ago in mice and strongly emphasize the key role of DC in viral immunity- Cell Institut Imagine

Congratulation to @beziatv et al. for a tour de force study showing that Flt3L deficiency strongly affects adult hematopoietic progenitors, B cells, monocytes and DC development while macrophages remained intact in humans. cell.com/cell/fulltext/…

Dr. M. Bernardo @realFlorentGinhoux Garett Dunsmore IRB Barcelona Gustave Roussy Cancer Cell Macrophages were our focus. The concepts may go beyond.

Looking forward to welcoming everyone to beautiful Killarney for #KSMyeloidTargets24 with co-organizer Max, and discussing how academia & industry can align their efforts to develop effective myeloid cell targeted therapies for cancer.

Out in Cell today! We describe the first humans with inherited, complete FLT3L deficiency. Despite a lack of most dendritic cells, they reached adulthood. See the thread below for the main highlights of our paper. cell.com/cell/fulltext/…

📢 Gustave Roussy célèbre la #RechercheClinique du 20 au 26 mai 2024 !

Cette année, un webinaire sur ✨Le système immunitaire pour soigner le cancer✨ se déroulera le jeudi 23/05 à 18h.

Plus d'informations à venir ⌛

Fascinating work!!!

OUT NOW!🥳
I am delighted to share my main PhD project done at Casanova Lab, just published Cell (cell.com/cell/fulltext/…). For the first time, we describe the FLT3LG deficiency in humans, leading to a profound reduction of the bone marrow cellularity and progenitors.

📰 Kick-off de l’IHU Prism Center :

Ce jeudi 2 mai s’est tenu à l’espace Maurice Tubiana de Gustave Roussy le kick-off de l’IHU #Prism , cofondé par CentraleSupélec, Gustave Roussy, l’Inserm, Unicancer et l’ Université Paris-Saclay.

Lire l'actualité ➡ gustaveroussy.fr/fr/kick-de-lih…

Excited to share our piece on how #time shapes macrophage heterogeneity and their functions in bridging #inflammation and #cancer , way before its onset.

Defining 'Pre-TAMs' in tumorigenesis and (pre-)malignant evolution

w/ @realFlorentGinhoux C. Blériot Garett Dunsmore IRB Barcelona 👇🏻