Steve Gygi Gygi Lab investigador del departamento de biología celular en Harvard Medical School impartirá una conferencia titulada 'Proteomics as a biological assay'

🗓️ Viernes 10 de Mayo
📍PRBB Auditorium (Barcelona)

Don't miss this preprint from our colleagues Ernst Schmid and Johannes Walter in Harvard Med BCMP. We expect their work with AlphaFold will be an important complement to many of our proteomics projects, from HMSBioPlex to PTM profiling, chemoproteomics, and more!

Cool paper from our neighbors Johannes Walter and Ernst Schmid in Harvard Med BCMP describes a new classifier for improving alphafold-based interaction screening. biorxiv.org/content/10.110…

Congratulations to Matt McHenry & the entire team, including collaborators Jim Wells Gygi Lab John R. Engen Thomas Wales, on the discovery of a covalent inhibitor of BAX, a blueprint for developing drugs to protect cells from unwanted cell death. nature.com/articles/s4158…

If you like protein interactions, don't miss this paper from Harvard Med BCMP members Ernst Schmid and Johannes Walter. They present a classifier that identifies confident AlphaFold structures of interacting proteins and use it to screen protein families in silico for new interactions!

We are committed to experimental profiling of protein interactions, but computational methods for predicting PPI are an important complement to our work. See this paper from Ernst Schmid and Johannes Walter to learn how they use AlphaFold to predict PPI's at scale! Harvard Med BCMP

Check out this paper to see how we're profiling more reactive Cys residues with less sample, thanks to the efforts of Ka Yang, Qing Yu, and other lab members! Harvard Med Cell Bio

Check out this paper from Gygi lab alumnus WeekesLab to see how they've used proteomics to characterize functions of several HCMV proteins! sciencedirect.com/science/articl…

Excited to announce I’ve been awarded a T32 fellowship with BIDMC CVI! I’ll continue working in Spiegelman Lab & Gygi Lab using proteomics to interrogate inter-organ signaling following exercise. Grateful for this opportunity to join an outstanding cohort & grow as a scientist.

Excited to talk about my transition to Spiegelman Lab & Gygi Lab on this panel with these amazing leaders in proteomics!

Keriann Backus Lisa M. Jones Lab Lindsay K Pino - @[email protected] US HUPO

Online now! Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input by Ka Yang, Steven P. Gygi Gygi Lab, Qing Yu, et al at Harvard Medical School dlvr.it/T0LgyJ #chembiol

Excited to see that our paper is getting some views! If you haven’t checked it out yet, take a look! We have also been testing this approach with single cell samples and are aiming to get another short note together around those data. Stay tuned!

I’ll be presenting some of the work we’ve been doing in the Walter lab to leverage AlphaFold multimer interaction screens to better understand biological pathways. Excited to be part of a fantastic speaker lineup!

I'm looking forward to speaking at this Harvard Medical School Center for Computational Biomedicine meeting on protein structure prediction! I'll be talking about integrating AlphaFold structural predictions with HMSBioPlex to dramatically improve our understanding of the interactome.

If you're into tardigrades, proteomics, or both, don't miss this CNN article featuring work that joint Gygi Lab and Spiegelman Lab postdoc Amanda Smythers, PhD did during her PhD with HicksLabMassSpec investigating how tardigrades survive in harsh environments! cnn.com/2024/02/05/wor…

Check out this massive study led by Gygi Lab member Jonathan Van Vranken and lab alumnus Devin Schweppe to learn how thermal stability measurements and small molecule screening can be used together to tease apart the compounds' direct and indirect effects!

If you can’t get enough of proteome thermal stability data, this is definitely the paper for you! Check out this massive study from Devin Schweppe and a bunch of Gygi Lab colleagues….

Next up is Bec Whitehouse from Gygi Lab discussing TMT multiplexing on the Thermo Fisher Orbitrap Astral #LorneProteomics2024

I’m very excited to share our new paper on modeling isobaric proteomics data! Thanks to my collaborators @Calico and for some excellent advice from Devin Schweppe, Martin Wühr and Gygi Lab. Time for a walkthrough. #TeamMassSpec
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Check out our latest paper to learn how Ka Yang, Qing Yu, and other lab members have streamlined our TMT-ABPP workflow to enable faster, deeper, and more sensitive cysteine profiling!