Excited to announce that Skolay (Skolay) is live on the appstore. We are building Skolay to enable 1:1 conversations between writers (authors, substackers, journalists) and their audiences. Huge thanks to our pioneering first authors and readers! Much more to come :)

🚨 New paper alert 🚨 I am so happy to share the first paper of my postdoc in Mizuno Lab . Here we hope to summarize the cellular landscape of neurons thru the lens of #cryoET . Hope you enjoy. authors.elsevier.com/c/1ivnv3PA3sYq…

The long-term vision of Ellipsis Labs is to improve global finance by an order of magnitude — to do this, sustainable markets are table stakes.

I’m fortunate to work with a talented team and thoughtful investors who believe we will achieve this ambitious mission.

We are delighted to announce a $30M contract with ARPA-H (ARPA-H) to develop the next generation of tissue-targeted cellular therapies.

Foci of the project include precision therapeutics for glioblastoma, multiple sclerosis, and Alzheimer's disease.

ucsf.edu/news/2024/04/4…

'Thinking Machines: Abstract thought as internal world model exploration' at Caltech's Chen Institute retreat!

So excited to share our preprint from the El-Samad lab on engineering multiple small molecule and cell contact-inducible systems for controlling gene expression and differentiation in mESCs!
biorxiv.org/content/10.110…

Congrats to Sarah Sarah Soliman on her first-first author paper and Zara zara weinberg 🧪🧙🏻‍♀️ on her first-last author paper!!!

🚨!! JOB OPENING !!🚨

Join us as a postdoc to investigate how 4D mitochondrial dynamics determine cell fate!

You can reach out to us at schoeneberglab.org/contact or use this web form: forms.gle/1AaEYW9a8vn56v…
Looking forward to hearing from you!

Pls RT friends🌞

Engineering an E coli strain for production of long ssDNA 🧬 biorxiv.org/content/10.110…

The latest from CDI: Degron-based bioPROTACs for controlling signaling in CAR T cells! Led by Matthew Kim of the Hana El-Samad and Andrew Ng labs! Check it out on bioRxiv.

Hana El-Samad Andrew Ng

biorxiv.org/content/10.110…

Exciting new work from Matthew Kim Cell Design Institute @UCSF: Genetically encoded 'bioPROTACs' for antigen-inducible, targeted degradation of key signalling molecules in CAR-T cells. Delighted to be a part of this team!

Andrew Ng Hana El-Samad

biorxiv.org/content/10.110…

🚨New Preprint🚨 We developed targeted protein degraders to degrade CARs and endogenous signaling molecules in T cells. The genetically encodable nature of these bioPROTACs enabled us to build a circuit to degrade ZAP70 and inhibit signaling in an antigen-dependent manner.

I've heard nothing but positive feedback from founders who participated in 5050—and am very lucky to support some of them.

Super exciting to see Fifty Years upping their game yet again and expanding this program.

Onward! 🧬🌱

I could not recommend the Fifty Years Fifty 50 program more highly!! I was impressed by the committment of the Fifty team (Ale Borda & Alex Teng fly across the country to run each session in Boston and SF!). Met some awesome people too. Apply!!

Come join our team Cell Design Institute @UCSF!

Engineered cells intelligently sense and respond to their environments with desired behaviors. We showed that de novo-designed protein binders can expand the sensing capabilities of 3 synthetic receptors, enabling new targets for engineered cells. biorxiv.org/content/10.110…

UCSF PROPEL An Tran (Lim lab) estimating the dose and testing specificity of a novel CAR T cell treatment! FDA application in process!!! Clinical trial starting later this year 🤞🏼🤞🏼

In a new review (part of an upcoming series in Immunological Reviews on cell therapies) Sara Capponi (Sara Capponi, IBM) and I discuss the potential of using AI to build predictive models that aid in development & understanding of cell therapies. doi.org/10.1111/imr.13…

Check out my good friend Conner Lambden Conner's platform Helium Trades – algorithmic news media bias analysis, AI generated sentiment analysis and summaries, and market analytics. Fun to search topics and see which outlets are most positive vs -tive.
heliumtrades.com

Hi everyone~ I am super excited to pre-print my PhD work 🍾
biorxiv.org/content/10.110…

See these fireworks (calcium signals)? These are your immune cells, and this is what happens when they talk to one another to try and organize the very earliest stage of your immune response!