A PARP1-TIMELESS alliance in cancer therapy dlvr.it/T77g9S

Genomic context sensitizes regulatory elements to genetic disruption dlvr.it/T75tXQ

G-quadruplex folding in Xist RNA antagonizes PRC2 activity for stepwise regulation of X chromosome inactivation dlvr.it/T742s0

Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants dlvr.it/T72l0D

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism dlvr.it/T72NhN

Our latest is out! 🥳We found cGAS engaged w/ ruptured micronuclei can't activate downstream signalling. Our observation challenges current dogma that cGAS binds to self-DNA in micronuclei and triggers innate immune signalling.
Spearheaded by Tohru Tohru Takaki with Rhona.

Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in Molecular Cell!

➡️cell.com/molecular-cell…

Karthik Gottemukkala, D.Sherpa, Arno Alpi

Schulman lab Max Planck Institute of Biochemistry (MPIB)

Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers dlvr.it/T727sh

Autophagy preferentially degrades non-fibrillar polyQ aggregates dlvr.it/T71rLm

An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins dlvr.it/T71dnN

The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics dlvr.it/T71P9D

GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies dlvr.it/T706Gn

Cancers can manipulate telomeres, which cap DNA, to help their own spread. Penn Medicine scientists just figured out how they do it Molecular Cell cell.com/molecular-cell…

Principles of chromosome organization for meiotic recombination dlvr.it/T6zl6Z

Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling dlvr.it/T6zV2R

Sohail Tavazoie and I preview cool work by The Agami Lab & co. in this issue of Molecular Cell: arginine limitation promotes cysteine misincorporation in the tumor proteome. Our preview is here: authors.elsevier.com/a/1j5vE3vVUPRm…. Definitely check the full article too! sciencedirect.com/science/articl…

Enhancer switching in cell lineage priming is linked to eRNA, Brg1’s AT-hook, and SWI/SNF recruitment dlvr.it/T6z9K3

Hear invited speaker Amy Gladfelter Gladfelter Lab discuss “The physical code of RNA in biomolecular condensates” Cell Symposia  #CSRNAs24 , October 20–22, 2024, Beijing, China. Submit your abstract before June 14, 2024 for a chance to join the program cell-symposia.com/rnas-2024/inde…

Online Now: Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING dlvr.it/T6sjzZ