A trial of children with #Type1Diabetes shows a single infusion of expanded #RegulatoryTCells failed to protect against beta cell decline, providing clues for future trial design and suggesting Treg quality as a critical factor in efficacy. Benaroya Research Institute scim.ag/6U4

Scientists leverage mutagenesis to create a new #influenza vaccine based on a cocktail of recombinant #hemagglutinin proteins, which directs immunity against more conserved regions and elicits broader and more potent immunity in animals. DukeMGM scim.ag/6Sd

A recent paper that combines antigenic analysis of #dengue with 2 decades of hospital data in Thailand unravels how different combinations of serotypes shape the risk of severe secondary infections in children. Henrik Salje Derek Cummings Lin Wang GeneticsCambridge scim.ag/6Qf

Scientists and health officials must redouble efforts to invest in #vaccine research programs, policy initiatives, and public outreach to support the health of an aging world, researchers argue in a new Viewpoint. Harvard T.H. Chan School of Public Health scim.ag/6PM

Brainstem connections that sustain wakefulness in human consciousness: science.org/doi/10.1126/sc…

Thank you Science Translational Medicine for featuring this work on the cover!

MGH Center for Neurotechnology and Neurorecovery Mass General Research Institute MassGeneral News MGH Neurocritical Care MassGeneralNeuroscience MGH Neurology MGH Martinos Center Boston Children's Massachusetts Institute of Technology (MIT) Brigham and Women's Neurology

A new #MachineLearning algorithm parses electronic health records data to scope out patients with a high likelihood of having common variable immunodeficiency, laying the road to earlier diagnosis and treatment. #CVID Manish Butte UCLA Computer Science scim.ag/6PB

'Vaccination for Healthy Aging'
We're seeing the potential for cancer vaccines. What if there were vaccines that promoted a durable, healthy immune response and prevented immunosenescence?
science.org/doi/10.1126/sc… Science Translational Medicine

Patients with immunodeficiency are often undiagnosed or experience marked delay in detection.
#AI to the rescue.
science.org/doi/10.1126/sc… Science Translational Medicine Manish Butte UCLA

Our paper on the role of antigenic space in determining dengue disease risk is out as a cover article Science Translational Medicine
science.org/doi/10.1126/sc…

Don't miss the new issue of #ScienceTranslationalMedicine ! An #AI system scans health records to detect rare immune disorders, scientists build an MRI atlas of human wakefulness, and a Viewpoint discusses the importance of adult vaccines in an aging world. scim.ag/6O0

A new EEG microdisplay for #neurosurgery conforms to the brain and employs colorful light patterns to visualize brain activity in large animals, potentially providing a more reliable method for surgeons to map and avoid functional brain tissue. UCSD Engineering scim.ag/6N4

What’s the source of IgE-producing cells in allergy?

Studying children with #PeanutAllergy , scientists found they harbor type 2-polarized memory #Bcells with mutated receptors that switch to pathogenic IgE production. Icahn School of Medicine at Mount Sinai #DayofImmunology scim.ag/6Md

An antibody for #Nipah virus that targets the prefusion F viral protein offers strong postexposure protection to small and large animals, providing a potential treatment and outbreak response tool for this merging threat. UTMB Health #DayOfImmunology scim.ag/6LX

Why do some pregnant women develop #HeartFailure ?

New clinical research ties peripartum cardiomyopathy and #preeclampsia to placental #senescence , but shows that targeting activin A can mitigate heart damage in mice. Anthony Rosenzweig, MD Mass General Heart scim.ag/6L0

A new paper that combines antigenic analysis of #dengue with 2 decades of hospital data in Thailand teases apart how different combinations of serotypes shape the risk of severe secondary infections in children. Henrik Salje Derek Cummings Lin Wang GeneticsCambridge scim.ag/6Km

The Eph/ephrin pathway is a core driver of vascular leak and endothelial damage in #sepsis but can be targeted effectively with an Eph decoy, show new experiments involving mice and samples from hospitalized children. NeuroComplement_Lab UQ Medicine scim.ag/6JF

Two decades of dengue surveillance reveal how different serotypes shape the risk of severe disease, colorful brain microdisplays could minimize the risk of tissue damage during neurosurgery, and more in the new issue of #ScienceTranslationalMedicine . scim.ag/6IE

A new #DeepLearning platform assists endoscopists with detecting high-risk esophageal lesions during routine #endoscopies , providing a powerful tool for earlier diagnosis and treatment of #EsophagealCancer . Wenzhou Medical University scim.ag/6HN

Why do some pregnant women develop #HeartFailure ?

New clinical research ties peripartum cardiomyopathy and #preeclampsia to placental #senescence , but shows that targeting activin A can mitigate heart damage in mice. Anthony Rosenzweig, MD Mass General Heart scim.ag/6GY