New position in our lab! Spread the word!

uni-giessen.de/karriere/stell…

A study in Nature Microbiology shows that enzymes found in the gut resident bacteria, Akkermansia muciniphila, can convert both known and previously not recognized antigens on human red blood cells to make group O blood. go.nature.com/3QLIPTh

How to keep up with literature and develop good habits? Try the Journal Club Blitz! biociphers.wordpress.com/2024/04/28/how…

A statistical approach for identifying single nucleotide variants that affect transcription factor binding Marcel Schulz - @[email protected]
cell.com/iscience/fullt…

Today first seminar of the critical #genomics initiative at Goethe-Universität . Prof. Dorothea Schulte talked about #DNA and how it decodes organisms. Every week on Wednesday a new speaker will address another topic including Anna Y. Yotova . More info here: critical-genomics.de/index_de.html

🧵1/10 We’re thrilled to share our latest paper, Bicycle, a novel approach for inferring cyclic causal relationships from observational and interventional data! This work addresses a critical gap in understanding complex biological networks.

If anyone doesn’t know, the {ggdist} package is THE package for plotting distributions. It produces absolutely gorgeous figures of analytic or data distributions. Aside from {ggplot2}, this is probably the package I use the most for dataviz.

'caQTLs and haQTLs capture regulatory variations not associated with eQTLs and explain ∼49% of the functionally annotated GWAS loci'

Been clear for a while that accessibility & histone marks provide more info for explaining & fine mapping GWAS loci than expression. 1/

How to pick a problem. Today in Cell. 1/53
cell.com/cell/fulltext/…

As my lab develops Seurat, I wanted to share some thoughts on the important Seurat and scanpy package selection preprint from Joseph Rich/Lior Pachter 🧵

The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs. Python. But do they produce the same results? In biorxiv.org/content/10.110… w/ Joseph Rich et al. we take a close look. The results are 👀 1/🧵

what a birthday present! 💃🏻💃🏻 Our paper characterising pericytes in cardiac ageing has just been published by Circulation Research -> ahajournals.org/doi/10.1161/CI… Special kudos to future Dr. Anita Tamiato who did the heavy lifting 💪🏻💪🏻

This is just amazing work. Wow.

Excited to share our work on G-quadruplex RNA-binding proteins, a fantastic collaboration with Orom Lab. Huge thanks to Alex, Ulf, Johanna, for this computational-experimental story nature.com/articles/s4146…

Thrilled to share our latest breakthrough in Nucleic Acids Research: 'Prediction of protein-RNA interactions from single-cell transcriptomic data.' Congratulations to Alessio, Jonny, and Alex for their contributions!
academic.oup.com/nar/advance-ar…

Wow! This is 💥 💥💥💥💥

cell.com/cell/abstract/…

Implications in heart and brain disorders, including age associated diseases

Happy to share our pre-print on #lncRNA recruitment of SWI/SNF to cell type-specific #enhancers .

We performed several sequencing experiments to reveal the mechanism for how the highly conserved and ubiquitously expressed SWI/SNF finds its DNA targets genome-wide.

Our preprint characterizing mouse developmental Enhancer—Promoter interactions by Zhuoxin is out today Nature Genetics rdcu.be/dBRPu

See also a complementary study on fly Enhancer—Promoter interactions from Eileen Furlong nature.com/articles/s4158…

NOW LIVE ON TAPE

Our ⁦Human Cell Atlas⁩ Webinar
“Focus on Technology”

Featuring: Spatial genomics, Lineage tracing, Perturbation and AI tools.

Starring: Samantha Morris, Nikolaus Rajewsky, Maria Brbic, Eric Lubeck.

Enjoy 👇👇👇 youtube.com/watch?v=fI9Oe_…

Our most recent work is now published at Nature Genetics. Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Great collab with Guillaume Bourque lab and huge congrats to the lead author Katie Aracena. Link: shorturl.at/bcdBP