From Protein Structures to Functional Biomimetics dx.doi.org/10.1055/a-2308…

It was a collaborative effort of Lars @LongLarf and Reuben Reuben B. Leveson-Gower to develop this system, supported by Henriette and Andy-Mark for a fantastic structural analysis.
Here’s the paper in nature: nature.com/articles/s4158…

Great talks of Professor Hiroshi Abe Hiroshi Abe Universität München and Universität Münster about Chemistry-based mRNA design within IRTG2678. 😊 Thank you so much for your visit 🙏

Previously ChemRxiv, the final version of this study is now out in Nature Communications.

doi.org/10.1038/s41467…

This naturally occurring 'non-native' nucleoside has been sitting right under noses for a long time.

New #phytocannabinoid (selective for #CB2receptor ) discovered in sweet #violet , published in JBC.

jbc.org/article/S0021-…

Congratulations to @ Natasa Tomasevic and all coauthors! Edin Muratspahic BeckerLab GertschGroup

Check out our work that just appeared in J. Am. Chem. Soc. on the development of the fastest organometallic Cys bioconjugation reagents: pubs.acs.org/doi/10.1021/ja…. Shout out to many UCLA Chem & Biochem collaborators on this project including: Maynard Group and Ken Houk.

Thiol-mediated uptake (TMU) is an intriguing enigma in current chemistry and biology. Our new paper in ACS Central Science provides a solid basis to understand TMU, enable and prevent entry into cells along at least three orthogonal dynamic covalent networks

pubs.acs.org/doi/10.1021/ac…

🤩🤩🤩 our work made it to the NatureStructMolBiol cover. And then for such a great issue 🤩🤩 thanks to Valeria Kalienkova 🇺🇦🌻 TimLynagh and Mowgli 🥳🥳 check Kat Ciazynska comments 👇🏼

Pascal Vermeeren wins KNCV-CTC Thesis Award🏆! Well done Pascal! 🎉 KNCV The TheoCheM Group VU Faculteit der Bètawetenschappen.

Very happy to share our newly published work 'On the Mechanisms of Hypohalous Acid Formation and Electrophilic Halogenation by Non‐Native Halogenases' Work by Kridsadakorn Nook Prakinee Aisaraphon Phintha VISTEC
onlinelibrary.wiley.com/doi/10.1002/an…

That's a wrap for the #MedChemFrontiers24 EFMC ACS Division of Medicinal Chemistry! See you in Spring 2025 for #MedChemFrontiers25 in CHICAGO, hosted by Terry Moore 🏳️‍🌈!

#medchem #chembio #drugdiscovery

After the great talk on 14-3-3 proteins by Luc Brunsveld, another impressive talk at #MedChemFrontiers24 is given by Tom Grossmann, describing examples of how obtaining bioactive proteomimetics from protein structures.
EFMC
ACS Division of Medicinal Chemistry

👇👇👇👇👇👇👇👇👇👇👇

Very interesting talk by Tom Grossmann at #MedChemFrontiers24 . He talked about his group's exciting work on peptidomimetics including (bi)cyclic peptides for addressing challenging protein targets including β-catenin. doi.org/10.1002/anie.2…

Here is the link to the paper pdf drive.google.com/file/d/1goans4…

Here it is! Credits for our Kaijun Su 🎉🙌🏼🎉

Very excited to start this ZonMw project! Together with Fred van Leeuwen Lab, we will investigate how cells selectively regulate tRNA genes. Two PhD positions available soon (NKI and AmsterdamUMC).
zonmw.nl/en/news/zonmw-…

We characterised the proteases of ten flaviviruses and identified broad-spectrum inhibitors. Pan-flavivirus drug discovery is important for our epidemic preparedness and response. Congratulations to Saan Voss ANU Research School of Chemistry. Published in Antiviral Research: doi.org/10.1016/j.anti…