In A&D Journals, we present one of the pioneering studies of #Alzheimer blood biomarkers in a cohort from the #Caribbean region.

Delighted to have worked on this with the Tobago Health Study group.

alz-journals.onlinelibrary.wiley.com/doi/full/10.10…

Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease nature.com/articles/s4146…

In Nature Communications, we validate plasma BD-tau as AD-type N marker:

- BD-tau is amyloid driven & assoc. w/ atrophy;

- Abnormal p-tau & BD-tau confers faster cognitive decline and atrophy;

- BD-tau is less responsive to kidney fxn effects.

tinyurl.com/3vmjpcfe

Fernando Gonzalez

In A&D Journals, we describe a new method for tau aggregates:
- specific to soluble/solubilized tau aggregates vs. monomers;
- applies to Alzheimer brain-derived homogenates🧠; and
- increases with Braak staging.

Next step: human CSF & blood 🩸

alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

In this paper led by my grad student Przemek in Gothenburg, we describe p-tau212 as a new blood biomarker for Alzheimer’s disease 🩸.
- Plasma p-tau212 had same accuracies as p-tau217.
- P-tau212 antibody stained tangle structures in postmortem brains.

nature.com/articles/s4146…

Brain-derived tau increases immediately after severe TBI and demonstrates utility to predict clinical outcomes.

Great collaboration with Göteborgs universitet / University of Gothenburg scientists and clinicians.

Fernando Gonzalez

Brain-derived tau quantified CNS tau in blood. How about peripheral tau in blood? And what are their clinical values across a range of acute and chronic human diseases? We continue to dissect these dynamics in our ongoing work.

We provide further preanalytical characterization of brain-derived tau (BD-tau) 🩸

~ 40% ⬆️ levels in EDTA plasma vs. paired serum.

Reagent batch changes do not affect assay performance and longitudinal trajectories.

Fernando Gonzalez

alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Check out this really cool publication from Bruna Bellaver and Pascoal Lab showing that astrocyte reactivity links amyloid and tau pathologies in #Alzheimers . nature.com/articles/s4159…

Great collaboration with Dr Emily Hill investigating functional electrophysiological effects of tau protein in human CSF. actaneurocomms.biomedcentral.com/articles/10.11…

🚨New paper alert in Neurology: Here, Pâmela Lukasewicz showed that changes in plasma p-tau181 and NfL have the potential to be used as surrogate biomarkers in large scale clinical trials targeting preclinical AD. João Pedro Ferrari-Souza Tharick Pascoal
👇👇👇
n.neurology.org/content/early/…

Great to have presented on the dynamics of brain and peripheral sources of tau protein in blood in different neurological disorders at #ADPD2023

We present an up-to-date review on plasma phospho tau with a focus on diagnosis and clinical trials …arneurodegeneration.biomedcentral.com/articles/10.11…

It's been an honor to be invited on multiple TV and radio shows to discuss our recent publication on blood BD-tau (tinyurl.com/yckcxte7)

Just a couple:

- BBC Newshour bbc.co.uk/sounds/play/w1…
(starting at 18:50)

- BBC News Arabic
tinyurl.com/mrymz8vu (large file)

I am delighted to note that the podcast I recorded for #DementiaMatters at Wisconsin ADRC was 'the most popular and most downloaded' episode of 2022. Thank you Nathaniel Chin for hosting me, and for your service to the #Alzheimers community. #ENDALZ

adrc.wisc.edu/dementia-matte…

.Brain highlights our paper on plasma/serum brain-derived tau in their tweet bit.ly/3Q4xUCv

Thanks to Alzforum for covering our work on the new plasma biomarker brain-derived tau.
tinyurl.com/yckcxte7

...Along with constructive comments from several respected colleagues including Suzanne E Schindler

It is an honour to share our latest article in Nature Medicine which highlights the use of different #blood #biomarkers for different #Alzheimer trial applications 🩸📈 🧠

nature.com/articles/s4159…

Oskar Hansson BioFINDER Göteborgs universitet / University of Gothenburg Wisconsin Alzheimer's Institute
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