Very excited to share our latest work, out today in Science Magazine, on the serendipitous finding that vitamin D ☀️ regulates the gut microbiome to promote cancer immunity🦠 science.org/doi/10.1126/sc… 🧵👇 Caetano Reis e Sousa The Crick

How does vedolizumab work in ulcerative colitis patients?

Researchers in a new Science Immunology study say the drug targets gut-associated lymphoid tissue. Learn more: scim.ag/6Im

'Insights from a recently published Nature paper from the The Powrie Lab allow us to better understand how our gut bacteria and T-cells live in harmony - knowledge that we hope can be harnessed to design better cancer therapies.'👏

cancer.ox.ac.uk/news/new-study…

An excellent summary of the last 5 years of my life. Haematologist by day, immunologist by night. Parenting day and night.

I am delighted to announce our recent Wellcome DA success with Dr Sophie Acton and Clatworthy Lab. Super exciting opportunity. If interested in joining our team as a post-doc please contact any of us for more info.

A wonderful dinner celebrating our recent nature paper! Such an enjoyable discussion of science and immunology. What an honour to sit at the table with leaders in the field - Fiona The Powrie Lab Sarah Teichlab Emily Dr Emily Thornton and Raquel Raquel Bartolomé-Casado

Strong team of clinicians, nurses and pharmacists from Oxford #EBMT2024

'Its not the number of T-cells, but their spatial configuration that matters for tumor removal. Spatial context is my favorite thing and The SchietiLab is demonstrating so beautifully in her talk #AACR24 and she is taking brilliant her ideas all the way to the clinic!

Thrilled to be sharing the wonderful news that work from our lab Yisu Gu Dr Emily Thornton and Teichlab Raquel Bartolomé-Casado has been published today in nature ! Go have a read to learn more about how tissue microniches shape Treg function in the intestines🎉nature.com/articles/s4158…

I am so happy to share that our study has been published today in nature ! 🎉This has been an absolutely fantastic teamwork between Dr Emily Thornton, Yisu Gu The Powrie Lab and Teichlab [Link: rdcu.be/dDzwx]

A new study, published in nature, reveals how T cells gain and maintain tolerance to gut bacteria.

Findings could be used to design better therapies for patients with inflammatory diseases of the gut.

Read more! ⬇️

kennedy.ox.ac.uk/news/new-study…

Yisu Gu Dr Emily Thornton

I am excited to share our paper in nature! Yisu Gu Raquel Bartolomé-Casado Teichlab The Powrie Lab and I collaborated across Wellcome Sanger Institute University of Oxford Kennedy Institute of Rheumatology and Nuffield Department of Medicine. We wanted to understand where and how Tregs in the gut become their best selves. nature.com/articles/s4158… 1/12

Review alert on how to study the immune system nowadays 👇🏽

'Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system'

rdcu.be/dzL1r

Thanks, Saez-Rodriguez Group for the invitation to contribute! Nature Immunology

Congratulations to Robert Samstein Diego Chowell Lipschultz Precision Immunology Institute & colleagues for a tour de forcestudy showing that MHC II genetics controls lung cancer risk - since MHC II mostly controls APC/CD4 T cells interactions these data further highlight the role of APC/CD4 in tumor immunity

Congratulations to Audrey Gérard and her team, who received £1.5 million in funding from Cancer Research UK for a new project to unravel the coevolution between cancer and the immune system! 🎉

Read about Audrey's project ⬇️

kennedy.ox.ac.uk/news/cruk-fund…

Gerard Lab

We are excited to share our latest collaboration with TuguesLab: 'IL-23 stabilizes an effector Treg program in the tumor microenvironment' by Tobias Wertheimer, Pascale Zwicky et al. out now Nature Immunology(nature.com/articles/s4159… )
Check out our “tweetorial” below 🧵 (1/8)

Don’t miss out on an amazing opportunity to attend the next Keystone Regulation of Barrier Immunity Meeting this February in Banff, Canada. Expect some exciting talks and explore the beautiful scenery❄️🏔️Sign ups are available at keystonesymposia.org/conferences/co…
#KSBarrierReg24

Last week we had the annual Powrie lab Christmas party! A massive thanks to Becky, Claire, and Nick for organising our dinner and activities - we had a great time playing games and exchanging Secret Santa gifts🎅🎄