“Almost 90% of US adults met criteria for CKM (cardiovascular-kidney-metabolic syndrome) & 15% met criteria for advanced stages”
Chronic inflamma👉insulin resist👉AdvancedGlycationEndProduct(AGEs)👉CKM
Dr’s ❤️ to compartmentalize but its all about the mito
jamanetwork.com/journals/jama/…

#AdvancedGlycationEndproduct (AGE)⏫liver matrix #Viscoelasticity (Collagen bundle network with shorter fibers & smaller angles), but not #Stiffness
#T2DM #NASH #MASH

A mechanosensitive integrin β1–Tensin 1– #YAP cascade (⏫by high Viscoelasticity) ⏫ #HepatoCellularCarcinoma

Todays Good News story.
Carrots Are Not the Only Good Food for Your Eyes – Eat Grapes If You're Getting Older. #GoodNews #Health #Eyesight #Food #Grapes #MacularPigmentOapacityDensity #MPOD #AdvancedGlycationEndproduct #AGE #NationalUniversityOfSingapore goodnewsnetwork.org/carrots-move-o…

increased fracture risk in #T2DM - and post- #RYGB bones is mainly driven by accumulation of #advancedglycationendproduct and macro-structural alterations, generating biomechanical dysfunctionality nature.com/articles/s4159…

I think It’s the AGE-DNA adduct N2-carboxyethylguanosine #advancedglycationendproduct I am sure that’s a common hashtag, right? Frida Michailidou, PhD @David_Lab_MSK ETH Zurich Laboratory of Toxicology