In Annals of Oncology, Guillermo Villacampa and coll. report on the association of HER2DX scores with pCR including according to treatment regimens, and on survival outcome according to pCR status 👇

annalsofoncology.org/article/S0923-…

Sara Tolaney Aleix Prat #PrecisionOncology #bcsm

Grateful to have the chance to present our combined #HER2DX analysis of APT & ATEMPT. HER2DX significantly predicted prognosis among 471 pts with small, node-negative HER2+ tumors. A pleasure to collaborate with Aleix Prat #PrecisionOncology Guillermo Villacampa REVEAL GENOMICS to conduct this analysis.

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Ada Waks presents further validation of #HER2DX at #ESMOBreast23
- HER2DX pCR score predicts pCR overall
- high pCR score predicts benefit from dual-HER2 blockade
- 🔼benefit of multiagent CT in pCR-medium disease
➡️Useful data to tailor anti-HER2 tx and chemo in HER2+ BC

#ESMOBreast23

HER2DX and pathological complete response in HER2-positive breast cancer: a combined analysis of 4 neoadjuvant studies

💥HER2DX may assist in the selection of neoadjuvant therapy in HER2-positive BC.

Presented by Dr. Adrienne Waks

OncoAlert ESMO - Eur. Oncology

Last day of #ESMOBreast23 and #HER2DX is still hot topic!!! ⭐️Christine Desmedt on Key Takeaways #HERDX scores and validations
#breastcancer
#precisiononcology

ASCP MAMATHA CHIVUKULA,MD,FASCP Dr. Bui Pathologist🌼 Israh (Khan)Akhtar A6: HER2DX is a 27-gene prognostic and predictive assay in early-stage HER2-positive breast cancer #HER2low #PathTwitter #BreastPath

ASCP MAMATHA CHIVUKULA,MD,FASCP Dr. Bui Pathologist🌼 Israh (Khan)Akhtar A6: HER2DX from SABCS22: #HER2low #PathTwitter #BreastPath pbs.twimg.com/media/FjV44sYW…

Q6: What do we know about the HER2DX genomic test for breast cancer?

#HER2low #PathTwitter #BreastPath #SABCS22

MAMATHA CHIVUKULA,MD,FASCP Michael Feldman Dr. Bui Pathologist🌼 Israh (Khan)Akhtar

Her2DX PCR score . Can it help to optimize neo adjuvant therapy in her2 postive EBC ? Probably yes . ESMO - Eur. Oncology #ESMOBreast23

📯New Clinical Case: female 49 yo cT2 cN0 HER2+ (ER 80%, PR 25%, ki67: 50%, HER2 2+ (FISH+), TILs 90%). Based on her #HER2DX test, which treatment would you select? #breastcancer #biomarker #precisionMedicine

Jee Hyun Kim at #ESMOBreast23 on biomarker-driven strategies in HER2+ BC. Genomic biomarkers predict prognosis beyond clinical factors. Assays integrating both like #HER2DX can better guide tx. More evidence available at the poster display tomorrow at 12.15 REVEAL GENOMICS

Juanmi Cejalvo Pablo Tolosa Ortega Don't now if it's the case with HER2dx but many of the biologically based models and trials in other areas are full of poor statistical modeling and lack prospective independent validation. Future is interesting but we aren't there yet. Til then, I stand by the SoC

Cc M. Bolton

42 years old, IDC grade 2 pT1a (2mm) pN0 ER 100% PR 90% HER2-positive (3+). No tumor available for HER2DX Aleix Prat #PrecisionOncology Eva M Ciruelos Sara Tolaney Paolo Tarantino Javier Cortes MD PhD Hope Rugo Rodrigo Sánchez-Bayona Pablo Tolosa Ortega Juanmi Cejalvo Nat #cancer_in_covid19#

REVEAL GENOMICS® ANNOUNCES POSITIVE TOP-LINE RESULTS FOR HER2DX® IN MEDSIR'S PHERGAIN TRIAL #her2 #breastcancer #bcsm ⁦Aleix Prat #PrecisionOncology⁩ ⁦Javier Cortes MD PhD⁩ 👏🏻👏🏻👏🏻 ots.at/presseaussendu…

A6: HER2DX was used to predict pCR in patients with HER2+ breast cancer following neoadjuvant THP (DAPHNe phase II) #HER2low #PathTwitter #BreastPath ⁦ASCP⁩

Aleix Prat #PrecisionOncology HER2Dx score development Clin+Gen may help: HER2Dx Risk Score: if low, safer to de-escalate to pacli +trastuz. Stage 2, 3: HER2Dx pCR Score: if both low: go for upfront surgery. If pCR High: may use single taxane + anti-HER2 as neoadjuvant! Beirut Breast Cancer Conference OncoAlert

Can Her2DX can be used to choose those Her2 positive pt who may not need chemo ? Probably yes. Aleix Prat #PrecisionOncology ESMO - Eur. Oncology #ESMOBreast23

Very exciting! HER2DX can help us really tailor therapy upfront for patients with early-stage HER2+ breast cancer!

#bcsm

First #HER2DX done in Hospital Clínic de València INCLIVA. Clinical case: Female 58 yo cT3 cN0 HER2+ (ER 0%, PR 0%, ki67 15%, TILs 35%). Based on her HER2DX result, which treatment would you select? #precisionMedicine #biomarker #breastcancer

Men are increasingly opting to put off treatment for low-risk prostate cancer, and doctors say it’s a good thing.

Jose Fernando Moura, PhD Paolo Tarantino It might help! Patients in the #HER2DX pCR-high group derive greater benefit from dual HER2 blockade, and little benefit from multiagent CT (anthra + taxanes) as compared with taxane alone. Data presented at #ESMOBreast23 . What do you think Aleix Prat #PrecisionOncology?

✨ The #Golden Age

youtu.be/-bYS9qcDMOw