Dr Vishnu former postdoc in my group presenting his work on HT-ECHO assisted chemistry and HT USP30 screening @IUPAC2023

We also used the power of the Cyclic IMS from MS_revolutION to blend #HDX -MS and molecular docking simulations to decipher the conformational dynamics and binding mode of #USP30 inhibitors
doi.org/10.1016/j.mcpr…

Our new work is now online in Molecular & Cellular Proteomics describing the molecular and structural interplay of debuiquitinase #USP30 inhibitors, which have therapeutic potential in #ParkinsonsDisease and #mitophagy disorders. Thanks to all Oxford Drug Discovery Institute and Cancer Research Horizons!
doi.org/10.1016/j.mcpr…

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation dlvr.it/RWNqn8

Another collaborative effort. This time we helped our collaborators in Liverpool to characterise a new USP30 inhibitor. USP30 is an interesting target in neurodegeneration research. biorxiv.org/content/10.110…

Novel #drug targets in the development of #mitophagy modulators. Representative protective mitophagy inducers have identified pharmacological mechanisms and specific drug targets, including modulation of NAD, SIRTs, USP30, p53, Nrf2, PINK1, MCL-1, and ROCK

Parkinson’s Progression Halted by Inhibiting Enzyme

Exciting breakthrough: Inhibiting USP30 enzyme in mice halts Parkinson's progression by protecting dopamine neurons. This research, published in Nature Communications, could pave the way for novel treatments to slow or prevent

I'm thrilled to announce that my 2nd first-author paper has been published in LifeScienceAlliance. Huge thanks to my co-authors and the reviewers for their invaluable contributions. #NIX #USP30 #NBR1 #Pexophagy #peroxisome Inst of Systems, Molecular & Integrative Biology CCI Uni of Liverpool Wellcome

life-science-alliance.org/content/6/5/e2…

Who else is headed to Gothenburg next week for AD/PD - Advances in Science & Therapy #ADPD2023 ?

I'll be presenting an update on Vincere Bio's USP30 inhibitor program for #ParkinsonsDisease . You can find me at Poster OD236 or check out the recorded presentation on the virtual platform.

First BioRxiv post from the lab: Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches biorxiv.org/content/10.110…

【Mission Therapeutics】
脱ユビキチン化酵素(DUB)の選択性低分子阻害剤を開発。特定のDUBを阻害し、特定のタンパク/機能不全タンパクの分解を促進する。USP30阻害剤がAKI, ミトコンドリアミオパチー, IPFで前臨床段階。Abbvieと神経変性疾患で提携。
missiontherapeutics.com
#PROTAC以外の攻め方

🔥 Parkinson’s Progression Halted by Inhibiting Enzyme
Source: BIDMC

👉neurosciencenews.com/parkinsons-enz…

#Parkinsons #Enzyme #USP30 #PD #Neurology

This #groundbreaking finding suggests a new therapeutic avenue that could #slow or even #prevent Parkinson’s progression.

Preprint ALERT! #mito_folks
We found that FBXO7 (PARK15; ntc in flies) is the Ub-ligase that provides the latent mito-Ub regulating basal mitophagy, which opposed by USP30 and later co-opted for PINK1-Parkin activity in vivo.
biorxiv.org/content/10.110…

Pexophagy occurs via distinct NIX- and USP30/NBR1-dependent pathways.

life-science-alliance.org/content/6/5/e2…

Finally out in PLOS Biology our latest on mitochondrial quality control in vivo!
#PLOSBiology : FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and p ... dx.plos.org/10.1371/journa…

Malte Gersche talking about mitophagy, lys6-linked ubiquitin and USP30 #biochemevent Biochemical Society

45% de la population mondiale n’est couverte par AUCUNE couverture sociale : ni prestations sociales pour la maternité, le chômage, la retraite ou la santé. #worldprotectionsocialreport International Labour Organization #USP30

Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30 tandfonline.com/doi/full/10.10…

More interesting things going on with #usp30 and #mitophagy LivUni Institute of Translational Medicine

Great news! Our article Elena et al., Dual role of USP30 in controlling basal pexophagy and mitophagy EMBO Reports embopress.org/doi/10.15252/e…
was #topcitedarticle 😀