ASCO #ASCO2024 #ASCO24 will be here in no time. Besides all things #crcsm and gian, couldn't be more excited to have the 1st in person gathering of the #globalonc CoP them team has put together a great agenda representing many diverse voices!

We got a podium presentation with an invited discussant at #ESMOGI24 .🙌🏾

💡Will be presenting the full set of results and long term follow up on our #NESTTrial 🪺.

🗓️Fri, 28.06.2024
🕟16:30 - 17:45
📍Room 1
✈️Munich, Germany🇩🇪 ESMO - Eur. Oncology

#CRCSM OncoAlert

cslide.ctimeetingtech.com/gi2024/attende…

The FDA has approved ColoSense™, a noninvasive, multi-target stool RNA screening test, for use in adults at least 45 years of age who are at average risk of developing colorectal cancer. #crcsm #oncology onclive.com/view/fda-appro…

🥁🥁🥁Tweetorial
FOxTROT, the 1st ph 3 RCT of neoadjuvant chemo (NAC) in locally advanced colon cancer
We report that NAC is
✅deliverable and safe
✅led to statistically significant reduction in cancer recurrence than upfront surgery
A 🧵 (1/14)
#crcsm
ascopubs.org/doi/full/10.12…

Check out Dr. Ibrahim Sahin Ibrahim Halil SAHIN, MD UPMC Hillman Cancer Center discussing Early-Onset CRC: A New Epidemic With Knowns and Unknowns

Full 📽️ on #VuMedi
👇
bit.ly/YOCC

#ColorectalCancer AwarenessMonth University of Pittsburgh
#OncEd #gicsm #OncTwitter #oncology #CRCSM #ColorectalCancer

NY relentless champions at #CallOnCongress Fight Colorectal Cancer met with relentlessness king Chuck Schumer’s team complete with #BlueForCRC nailfies, #StrongArmSelfies Thank you for a lifetime of support for #crcsm community to get EQUITABLE access to screening, early detection, and treatment

🎉 Excited to stay on as Assistant Professor in GI Medical Oncology at MD Anderson Cancer Center after graduation. Immensely grateful to my mentors & the support of my family and friends. Thankful to our patients and looking forward to working together to #EndCancer 🚀 #CRCSM #CCAhope

Dr. Carolina Bernabe presents updates in GI/GU! #crcsm #LEAD23

#GI24 ASCO
CHECKMATE 8HW 🫳🎤
dMMR mCRC - nivo + ipi1
Dr Thierry Andre
📌 PFS HR 0.21, p<0.001 ⭐️
📌 2y PFS rate 72% v14%
➡️ No early crossover of the curves! 🙌
➡️ replaces pembro as SOC in 1L dMMR mCRC
OncoAlert #CRCsm

Sotorasib + Panitumumab improves PFS in pts wir KRAS G12C mut metastatic #colorectalcancer !

No new safety signals.

#crcsm 💙

#ESMO23 OncoAlert 🚨

Star fellow ⭐️⭐️ Tara Davidson giving an incredible review of the history of KRAS at our first back to in person GIMO journal club #crcsm

A 8-3
PRIME-RT is an ongoing p2 RCT comparing:
SC-RT + Durva → FOLFOX-Durva
vs.
LC-CRT + Durva → FOLFOX-Durva

❓Can the addition of ICI ⬆️ organ preservation rates by ⬆️clinical complete response
❓Can ICI-RT prime the systemic anti-tumor immune response
#CRCTrialsChat #CRCSM

A 2-8

📌 LARC (cT≥3 or cN+) is heterogeneous!

📌Select patients with upper rectal cancers amenable to sphincter-preserving surgery and no other high risk features may potentially omit radiotherapy and/or systemic therapy
More on this later!
#RectalCancer !
#CRCTrialsChat #CRCSM

#GISeries : Here we🗣️about the U.S. FDA approval of #Fruquintinib from #FRESCO2 & how it fits in our Rx paradigm w/Arvind Dasari, MD, MS

Full Int:
- targetedonc.com/pivotal-practi…
- oncbrothers.com/JC-FRESCO2
- Also on the “Oncology Brothers” podcast

#OncTwitter #MedTwitter Targeted Oncology #crcsm

So proud of my mentee Thejus Jayakrishnan, great job presenting our work on metabolomic differences between young-onset and average-onset CRC.
We found:
⚡️Citrate is significantly more abundant in aoCRC
⚡️Arginine biosynthesis and TCA cycle are ⬆️
#ASCO23 #CleClinicCancer #crcsm

A little late….but #gi23 I’m a proud supervisor (again!) Chris Williams presenting data on cd3/cd8 as a prognostic and predictive marker in stage 2 colon cancer (yes that is a merit award you see 🤩).
Keep an eye on this one…. #crcsm

Thank you to the 2023 Endowed Women Who Conquer Cancer YIA Conquer Cancer, the ASCO Foundation for supporting our research to better understand genomic and non-genomic mechanisms of resistance to anti-EGFR therapies in CRC #crcsm Thanks to my mentors Scott Kopetz Christine Parseghian, MD and pt advocate Manju George MVSc PhD Rectal Cancer Survivor

Current non-metastatic #RectalCancer tx-related Issues?

Issues that can arise if Sx is needed:
📌Low anterior resection syndrome (if rectal surgery)
📌Potential for urinary and sexual dysfunction
#CRCTrialsChat #CRCSM

#GI24 my favorite. Congrats to Rachna Shroff, MD, FASCO & team for another great year. ❤️ 🧠 full+ got training 🏃‍♀️ s in. Most compelling for me #CRCSM ipi/nivo vs chemo curves & 2yr dfs (await nivo data but a soc option). Also, look forward to more MSS localized bot/bal data Pashtoon Kasi MD, MS

A 2-3
Factors that may influence the 🔥 of CRC?
📌MSS=> Normal state of cells
📌MSI-H=> Mismatch DNA Repair pathway is defective, so cellular DNA harbors many mutations
❓What makes an MSI-H tumor hotter? MSI-H tumors usually have a higher TMB👇👇👇
#CRCTrialsChat #CRCSM