1/4 HIV insert in the SCV2 'S' 'HKNNKS' is contained in a HIV strain held at WIV. GTNGTKR is found in HIV but also a # of other coviruses. In Mimivirus it maybe the motif binds cyclophilinA/B. A recent study looked insilico & finds a bound conform ref: Korean invivo study is +ve

Targeted SiRNA Delivery to Treat Multiple Myeloma: Nanoparticle-mediated

techietonics.com/health-tonics/…

#research #biotechnology #innovations #multiplemyeloma #cyclophilinA #bloodcancer #targetedSiRNAdelivery #silencingCyPA #nanoparticlemediated

簡易版AF2使って、CyclosporinとCyclophilinAの複合体構造（1CWH）で遊んでみた。左が実測、右が予測。
近いところに寄って行ってはいるのだが……。流石に環状ペプチドは厳しいのかな
#AlphaFold #AlphaFold 2

So excited to announce that Kyusik Kim
will be presenting his PhD thesis on June 5th with quite a list of invited dignitaries, including:
@Sara_Sawyer_
Epididymosome
Kate Fitzgerald
@melissamoorelab
ErikSontheimerLab
@GSBS_UMassMed @UMassMedical
#HIV -1 #TRIM5 #CyclophilinA

The precise sequence of steps and partners involved in moving viruses and other macromolecular cargoes through the 30-protein nuclear pore complex (NPC) remains unclear...

🔗genetex.com/MarketingMater…

#HIV1
#NuclearEntry
#Capsid
#Nucleoporins
#Nup35
#Nup153
#POM121
#cyclophilinA

Genetic risk factor for Alzheimer’s disease impacts the blood brain barrier #cyclophilinA ... tinyurl.com/d75ltxj

Fragment based drug discovery for cyclophilinA: Novel ligands discovered and their binding constants determined by crystallographic methods.

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections? news-medical.net/news/20221102/… #SARSCoV2 #COVID19 #CyclophilinA

📢 New Paper online: Conformational and functional regulation of the chicken tumor virus number 10 (CT10) regulator of kinase II (CrkII) adaptor protein by cyclophilin A🧬🔬
Read more: explorationpub.com/Journals/ei/Ar…
#CrkII #CyclophilinA #SignalTransduction #TCellActivation

Drs. A Catic Andre Catic, L Maneix, P Iakova et al have uncovered the secret of long-lived #stemCells . Nature Cell Biology Huffington Center on #Aging #DisorderdProteins #cyclophilinA #hematopoieticStemCells #longevity CPRIT blogs.bcm.edu/2024/04/30/fro… via BCMHouston

Charles Brenner, PhD Not sure about astros, but if the cDNA synth is accurate (& clean) CyclophilinA is nice b/t peripheral cell types. If not, I look at TBP & Rps18 first before alts. RE of target(s) always 1st thought - I favor *modest* to low ubq expression ref vs. targets

Yoshinori N Ohnishi サンプル36か、、うちのは384のブロックがないんですよ!!!私もスタンダード置いてないです。CyclophilinAと比べています。

Yoshinori N Ohnishi うちのラボではエクセルでPOWER(2,cyclophilinA-sample)で％で出しています。多分どこでも同じような計算式だと思います。蛋白とRNAだと結構違うのもありますよね。

Yoshinori N Ohnishi 私はRNAを見てるのでWesternでコントロールになるのかはわかりませんけど、それぞれのサンプルでだいたい発言が同じものと比べれば、％CyclophilinAであがったり下がったりを見てます。私が確率した訳じゃないけど、この方法でやってきてるみたい。

Alex Speed Once made about a gram of the protein CyclophilinA for an experiment, which, if you buy here, is worth about $2.4M.
prospecbio.com/cyclophilin-a_…

Q6: Brad Berk & Chao Xue - how can you selectively target #cyclophilinA in vivo to treat vascular disease in #pulmonaryhypertension ? and do you think this strategy could also be useful in other #hypertensive #vasculardiseases ? Hypertension #HYPHIP

#CyclophilinA predicts clinical outcome in patients with congestive #heartfailure undergoing biopsy therph.co/T-