Macrovascular contribution to resting-state fMRI functional connectivity: direct.mit.edu/imag/article/d…
'These findings highlight the extensive contribution to rs-fMRI BOLD & FC predominantly by large veins, but also by large arteries.'
Also relevant for #fNIRS .

Whatever be the aetiology of diabetes, low carb approaches helps everybody.
Not just for microvascular disease but also to prevent fatty liver and cirrhosis along with better prevention of macrovascular disease.

Hmm.....

🩸🧠Treatable causes of intracerebral haemorrhage

⭕️ Several macrovascular disorders
🗝️Key features seen on brain MRI and/or CT
💡 Clues for diagnosis

via: Nature Reviews Disease Primers

#neurotwitter #NeuroTwitter #NeuroRad #MedTwitter #MedStudentTwitter #MedEd #EndNeurophobia #Neurology

🧫 Vascular lesions in MASLD
🎤Wilco Kvvanten
🐁Evidence of vascular dysfunction in rodents
🔬inflammation, oxidative stress, lipotoxicity
Affects micro/macrovascular beds
🩺 Clinical translatability?
#SLDSummit 2023! Sven Francque Jeffrey V. Lazarus EASL Education European Liver Patients' Association Sophie Lotersztajn

Presence of microvascular hypoperfusion despite complete macrovascular reperfusion is rare and could partially explain reasons for poor prognosis among these patients, while presence of microvascular hyperperfusion did not negatively affect the outcome. Adnan Mujanović

New paper in Imaging Neuroscience by Xiaole Z. Zhong, Yunjie Tong, and J. Jean Chen:

Assessment of the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla

doi.org/10.1162/imag_a…

This #MetaAnalysis has shown that #MetabolicSurgery reduced the risk of any cardiovascular event by 44% in patients with T2DM.

It also significantly reduced the risk of mortality and of all macrovascular outcomes.

#VisualAbstract

soard.org/article/S1550-…

❕Concurrent nivolumab and external beam radiation therapy for hepatocellular carcinoma with macrovascular invasion: A phase II study

🔓 #OpenAccess at 👉jhep-reports.eu/article/S2589-…

#LiverTwitter
#HepatocellularCarcinoma
#HCC

✅ 6 weeks.
✅ 21 obese women.
✅ Low carb diet (10% carbohydrate, 60–62% fat, 28–30% protein)

RESULTS:

✅ Macrovascular endothelial function (ability of the largest blood vessels in your body to work properly) did not change.

✅ Microvascular endothelial function improved

New year, new publication today in JAHA 🎉 ! Our outstanding team led by #ScottGrubman and #MiguelAlgara explored The interplay between micro and macrovascular disease and the impact of outcomes in peripheral artery disease in the US! Now published in JAHA 👇 👇 👇

We all know that Diabetes is a risk factor for heart attacks, stroke and peripheral vascular disease. #Insulinresistance leads to these macrovascular complications even before a diagnosis of Diabetes is made!
Some simple indicators of insulin resistance include
1. Abdominal

NOT ALL DIABETES IS THE SAME:

🔺 Pts w DM & preop micro or macrovascular complications are 2️⃣ times less likely to achieve remission after RYGB or SG

🔺There is an additive effect: greater number of complications associated with lower remission rates

link.springer.com/article/10.100…

Intracerebral #haemorrhage can be caused by several macrovascular disorders.
#stroke

go.nature.com/3JkDJbS

#MondayTip

#No_Reflow

👉Dysfunction of the #microvasculature despite macrovascular #recanalization

Mechanisms:
🛑 Microvascular Occlusion
🛠️(inmediate) Vascular Remodeling
✋Stalled Neutrophils
🚦Large Vessel Occlusion

🔗ahajournals.org/doi/10.1161/ST…
Stroke AHA/ASA

#Covid19 ▶️Coagulopathy alongside micro- and macrovascular thrombotic events.

4⃣ years into #COVID_19 pandemic
JeanConnorsMD Jerrold Levy, MD #CovidIsntOver jthjournal.org/article/S1538-…

The door is open and it is good ! #Liver transplant could be done in hepatocellular carcinoma with macrovascular portal invasion after response to immunotherapy respecting a washout period for IO before LT ! ILTS ILCA Agence de la biomédecine Gustave Roussy ESMO - Eur. Oncology AP-HP AFEF

The global economic burden associated with Type 2 #diabetes (T2D), a complex disease characterized by hyperglycemia, was estimated to be as much as $966 billion in 2021, most of which was caused by T2D-related micro- and macrovascular complications.

Intracerebral #haemorrhage can be caused by several macrovascular disorders. #stroke
go.nature.com/3JkDJbS

Looking to expand your trigeminal neuralgia expertise? Join Dr. Jeffrey Steinberg at #2023CNS to learn surgical techniques for vessel transposition for macrovascular decompression. #UCSDatCNS