Science is publishing an Erratum for the October 2001 Report 'Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.'

Learn more: scim.ag/6EG

Protein phosphorylation on a single site can alter the fate of the entire cell. This #mSystems review highlights that phosphosignaling in bacteria is all but certain to hold answers to many questions about bacterial physiology & pathogenicity. asm.social/1OQ

Check out our shiny app to explore meiotic phosphorylation!! meiphosprot.bio.ed.ac.uk

#meiosis #phosphorylation #proteomics #yeast #meiosis 4eva

1. What becomes of oxygen we breathe?

Oxygen plays a role in a variety of cellular processes, including sterol and fatty acid synthesis, and is critical for oxidative phosphorylation (8). Thus, it is not surprising that changes in oxygen availability can have drastic effects…

SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19

❗More and detailed evidence how SarsCov2 f.cks with your cellular power plants: MITOCHONDRIA

➡️'SARS-CoV-2 strongly inhibits mitochondrial oxidative phosphorylation (OXPHOS) resulting in increased…

Explore in Nature Communications how #disease mutations on phosphosites impact #protein -protein interactions with detailed follow-up on GATAD1.
Kicked-off during my PhD times with JSPS 独立行政法人日本学術振興会（学振） and now taken to the next level Selbach Lab by Trendelina Rrustemi. Big thanks!

nature.com/articles/s4146…

THEMIS2 has an inhibitory role in the antitumor activity of NK cells via GRB2 & phosphorylation of SHP-1 and SHP-2 near DNAM-1 and NKG2D J Immunol
doi.org/10.4049/jimmun…

📣 Our new paper on AARS2- related oxidative phosphorylation deficiency type 8 is now published in pedneurojournal. Congratulations to Elizabeth Pickup and co-authors for the amazing collaborative efforts. sciencedirect.com/science/articl… Andrea Gropman Child Neurology Society Children's National Hospital 🏥

Janiesaysyay But wait, there's more...on p53 suppression....once again excess phosphorylation is THE KEY !!

Yale School of Medicine Learning from Dr. Jonas Yale School of Medicine about “leak metabolism” involving ATP Synthase as a bridge to oxidative phosphorylation. There are pharmacological tools and evidence this impacts cell fate decisions in development. #226ICC

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation go.nature.com/2IUZm2a

Janiesaysyay Here’s a little more voodoo that phospholipids bind to Fibronectin-Fibrinogens along with spike protein via phosphorylation...

NEW FROM MBoC

PKA drives the phosphorylation of different proteins in different conditions to tune the output of the pathway over time, and in response to different stimuli.

molbiolcell.org/doi/10.1091/mb…

Pre-Panam2024:
“Current Perspectives in Pathophysiology”. 4th Symposium: Novel proteins and PTM. Autism, Down syndrome, phosphorylation heart, crosstalk, adipose Jorge Manzo Denes #valentinaparra ACCDiS #genarormz UTRGV #perlaprz Esc. de Medicina y Ciencias de la Salud #TecSalud Institute for Obesity Research Universidad Veracruzana

Dr Stacie King Noelle Richard Hirschman Inner membrane of vessels coated with natural phospholipids which expose phosphorus ‘heads’ upon damage or inflammation, activating fibrinogen ‘wound-healing mechanism’. If same injected directly into bloodstream followed by sustained phosphorylation from spike, you get these

The improvement of mitochondrial function was associated with increased levels of oxidative phosphorylation complexes.
The cellular mitochondrial mass was unchanged.

The improvement of mitochondrial function was associated with increased levels of oxidative phosphorylation complexes.
The cellular mitochondrial mass was unchanged.

Yale School of Medicine It is challenging to make all the connections in the phosphorylation networks. We need to understand specificity in catalytic site interactions to identify new targets.

PKA phosphorylates 500 sites and so easy to figure out what it’s recognize motifs but not the case for other

CD62L together with CCR7 are known FOXO1 target genes, so we wondered whether UroA can affect FOXO1 activity. Indeed, UroA promotes nuclear retention and transcriptional activity by reducing FOXO1 phosphorylation, which negatively regulates FOXO1 nuclear localization.

Phosphorylation of KRP3, a KIP-related protein by MPK3 modulates rice tiller and seed number by fine-tuning cell division biorxiv.org/cgi/content/sh… #bioRxiv