Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and

Rapamycin was the first drug definitively shown to extend lifespan in mammals—but there’s room for improvement. In this episode, Joan Mannick tells us how Tornado Tx is developing potent rapalogs to treat age-related disease.

🎧 player.captivate.fm/episode/bb9d9d…

Rapamycin-and-other-rapalogs-have-potential-to-delay-cancer

news-medical.net/news/20230418/…

Anticipating the arrival of the next wave of rapalogs.
Joan Mannick ARDD Meeting #ardd2023

Mikhail V. Blagosklonny, MD, PhD I would consider re-wording the last sentence in the opening paragraph such that it announces the intentions for the rest of the article.

E.g. 'In this article we will explore existing data which suggests rapalogs have the ability to delay or prevent cancer'.

New systematic review of the impacts of rapamycin & rapalogs on human organ function: “Rapamycin and its derivatives improved the immune, cardiovascular, and integumentary systems in healthy individuals or individuals with ageing-related diseases.”

You probably should know that there is a large number of topical formulations of various rapalogs; some are generics and, in many countries, are sold over the counter. These are formulated to penetrate the skin. But nothing with a chance of working is without side effects. These

Its gratifying seeing our paper picked up by the news. Thank you Anna Drangowska-Way for this well-written article. Lifespan.IO. #rapalogs #rapamycin #mTOR #longevity #ai #drugdiscovery
lifespan.io/news/using-ai-…

A reason to go easy on the fisetin and #rapalogs until we know more?

Introducing Amy Yadev as one of our 2023 AGE Early Career Scholars! Amy is a postbaccalaureate researcher at UW–Madison. Her research focus is testing rapalogs in insulin-resistant older adults. #AGEScholars #AGETC

Dr. Evelyne Yehudit Bischof ARDD Meeting Nature Medicine Thomas Rando Stanford Center on Longevity Michael Ringel, JD PhD Boston Consulting Group Insilico Medicine Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) Longevity Education Team Nir Barzilai Joan Mannick, the Co-Founder and CEO of Tornado Therapeutics talks about longevity medicine therapeutics, applied geroprotective interventions and rapalogs #ardd 2023 #ardd

Co-chair Justin Eyquem UCSF Helen Diller Family Comprehensive Cancer Ctr reviews synthetic immunology to build better CARs Society for Immunotherapy of Cancer Adding or removing ITAMs, inserting JAK3/STAT3/STAT5, another CD3z, Rapalogs, SNIP, synNotch can modulate function. Can also rest cells with Dasatinib to block tonic signaling. #CIWS23

Daniel Gilbert Here is a interesting episode about research on rapamycin, rapalogs and other mTOR inhibitors.

youtu.be/f1b4sxLQD08?si…

Aleksey Belikov Krister Kauppi - Longevity Lifestyle Hacker Great questions!

1. mTOR inhibition extends lifespan. The top hit is an mTOR inhibitor (just not rapa).

2. Rapa and rapalogs have very poor solubility that prevents testing high doses reported to extend in literature.

Here's a discussion: youtu.be/eedfbvCWq0k?fe…

Anti-Aging Effects of Rapalogs Extend Lifespan, Decrease Tumor Burden dlvr.it/StKXXR

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺 Mikhail V. Blagosklonny, MD, PhD Interesting summary, but still on the fence with rapamycin. Scheduling gets even more complicated with rapalogs (ad pubs.acs.org/doi/10.1021/ac…)...this is where the layman gives up and patiently waits for trials to progress...

Anabolic intervention pre se does not prolong life. Rapalogs module that response.

skin aging has new treatments this combines senolytics , collagen boosters, decrease inflammation. Can start with retinoids then go to peptides, rapalogs (rapamycin like meds) , injections, and technology

Here is a systematic review of all the evidence on rapamycin and rapalogs
thelancet.com/journals/lanhl… The Lancet Healthy Longevity