The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology

🔎'Senolytic therapy reduced AF inducibility in MI rats... and attenuated LA fibrosis...'

Mozhdeh Mehdizadeh Stanley Nattel

academic.oup.com/cardiovascres/…

📢 Epilepsy-linked Focal Cortical Dysplasia is due to somatic mutations in mTOR pathway genes🧬. Our study reveals cellular senescence in mutated neurons & senolytic drug efficacy in reducing seizures in mice🧟‍♀️ DOI: 10.1038/s41593-024-01634-2.

Watch an #aging short video of this #trendingwithimpact research #paper : “Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions.”
TruDiagnostic Buck Institute Cornell University

doi.org/10.18632/aging…
#aging

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy
nature.com/articles/s4159…

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy dlvr.it/T6WnsK

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis: buff.ly/4btiPE6

UCSF School of Medicine
#Aging #Pulmonology

In the male cohort no rapamycin is worse than control? But ONLY rapamycin is about as good as control? This is an anomaly.

Senolytic is ineffective while the SC seem to work. In the females it's reversed. Interesting if it's not noise.

ฅNya! Here's the latest 🗞 from [ Nature Neuroscience ]: ' Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy' 🔗: nature.com/articles/s4159…

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy | Nature Neuroscience nature.com/articles/s4159…

Targeting pathological cells with #senolytic drugs reduces seizures in a model of neurodevelopmental mTOR-related #epilepsy (focal cortical dysplasia type II)

Stéphanie Baulac Institut du Cerveau - Paris Brain Institute Jean Christophe Poncer 🇪🇺

nature.com/articles/s4159…

nature.com/articles/s4159…

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy | Nature Neuroscience nature.com/articles/s4159…

This is a cool study!
'Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy'

Qualia Senolytic Review youtu.be/qAsa723_jrM?si… via YouTube

Listen to an #audio version of a #pressrelease about the #researchpaper , entitled, '“Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions.'

soundcloud.com/aging-us/a-lon…

#aging #soundcloud #podcast #oa

Targeting pathological cells with #senolytic drugs reduces seizures in neurodevelopmental #mTOR -related epilepsy 🧠🧠🧠

Théo Ribierre Bacq Alexandre Stéphanie Baulac
nature.com/articles/s4159…

'These findings support the hypothesis that microglia are a primary target for senolytic treatments in AD.'
#AlzheimersDisease #imaging #senescence

📣 New collaborative paper out! We show in postoperative brain tissue from FCD patients that interictal activity originates from regions highly enriched in dysmorphic neurons. Targeting these cells with senolytics prevents seizures in an FCD mouse model.
nature.com/articles/s4159…

Aubrey de Grey What is the end point of these studies how will they be translated into human clinical trials. Same treatments similar methodology on humans? Also fisetin is a better senolytic as per recent studies and human trials are about to conclude at mayo clinic as well seems better choice