Pat Sheehan(@patwsheehan) 's Twitter Profile Photo

After a number of in vitro experiments, we moved in vivo and found that astrocyte-specific Bag3 over-expression was sufficient to reduce synuclein pathology.

After a number of in vitro experiments, we moved in vivo and found that astrocyte-specific Bag3 over-expression was sufficient to reduce synuclein pathology.
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Epoch Inspired(@EpochInspired) 's Twitter Profile Photo

❤️ 'Having a child with Down syndrome might be unexpected, it might come as a shock, but it is not a bad thing.'

buff.ly/3Ayegb8

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❄️시오(@_12276) 's Twitter Profile Photo

오래된 옷장의 문틈이 불쾌한 소리를 자아냈다. 지팡이를 쥔 손에 힘이 더욱 들어갔다. 문틈 사이로 검은 연기같은것이 미끄러져내려오는것 같기도 했다. 지훈은 지팡이의 끝을 그것에게 가져다 댔다
그것은 곧 정신없이 형체를 바꾸더니, 결국 한 사람의 모습을 했다.

너무도 익숙한 한 사람.

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숩숩✨️🪽(@synuclein0621) 's Twitter Profile Photo

평균 키 약 180 되는 건장한 청년 네명이 팔찌에 잇는 그림 하나하나 그렸을거 생각하멵

평균 키 약 180 되는 건장한 청년 네명이 팔찌에 잇는 그림 하나하나 그렸을거 생각하멵
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🪽화산✨(@hwasan0515) 's Twitter Profile Photo

어깨에 손 올리기 좋아하는 사람과 허리에 손 올리기 좋아하는 사람 둘이서 왈츠 추시오

어깨에 손 올리기 좋아하는 사람과 허리에 손 올리기 좋아하는 사람 둘이서 왈츠 추시오
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Bruno A. Benitez, MD(@B_A_Benitez) 's Twitter Profile Photo

An BMAL1-BAG3 axis protects against alpha-synuclein & pathology | The chaperone is a GWAS hit & prevents protein aggregation | by an amazing team lead by Pat Sheehan Albert (Gus) Davis MusiekLab via Neuron sciencedirect.com/science/articl…

An #astrocyte BMAL1-BAG3 axis protects against alpha-synuclein & #tau pathology | The #autophagy chaperone #Bag3 is a #parkinsons GWAS hit & prevents protein aggregation | by an amazing team lead by @patwsheehan @GusDavisLab @ErikMusiek via @NeuroCellPress sciencedirect.com/science/articl…
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Pat Sheehan(@patwsheehan) 's Twitter Profile Photo

Very happy to finally present my PhD paper in the Musiek lab where we find astrocyte activation via loss of Bmal1 abrogates intra-neuronal tau/synuclein pathology! We also find Bag3 upregulation in a cluster of astrocytes in human AD patients that resemble DAA astrocytes! 👇

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Kao Lab(@AimeeKaoLab) 's Twitter Profile Photo

🎉 Kao Lab celebrating Dr. Paul Sampognaro and Dr. Molly Hodul for their published research paper! 📚🌟🎉

Learn more about how mutations in α-synuclein, TDP-43, and tau hinder lysosomal degradation, extending their half-life: …arneurodegeneration.biomedcentral.com/articles/10.11…

🎉 Kao Lab celebrating Dr. Paul Sampognaro and Dr. Molly Hodul for their published research paper! 📚🌟🎉 

Learn more about how mutations in α-synuclein, TDP-43, and tau hinder lysosomal degradation, extending their half-life: …arneurodegeneration.biomedcentral.com/articles/10.11…

#lysosomes #Celebration
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Kessler Group Oxford(@kesslerlabox) 's Twitter Profile Photo

Great to see another successful collaboration published. ubiquitination mediates endosomal trafficking, out now in
Science Advances. Congrats to George Tofaris, Roman Fischer, and everyone else involved!

Check it out here:
science.org/doi/10.1126/sc…

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Irantzu Pallarès(@IrantzuPallares) 's Twitter Profile Photo

Featuring another terrific session at the FASEB Conference. If you are curious on the architecture of toxic and how they transition to fibrils Don’t forget to check out our poster P29!

Featuring another terrific session at the @FASEBorg #protein #Aggregation Conference. If you are curious on the architecture of toxic #synuclein #oligomers and how they transition to #amyloid fibrils Don’t forget to check out our poster P29!
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Janiesaysyay(@janiesaysyay) 's Twitter Profile Photo

Parkinson's begins in the gut. -Stephanie Seneff

SARS2 spike protein eliminates a good portion of the the gut's 😇 bacteria, bifidobacteria. -SabineHazanMD

Does this microbial change allow for the growth of harmful,🦠 which acts in a prion-like way forming alpha-synuclein? >

Parkinson's begins in the gut. -Stephanie Seneff
 
SARS2 spike protein eliminates a good portion of the the gut's 😇 bacteria, bifidobacteria. -SabineHazanMD

Does this microbial change allow for the growth of harmful,🦠 which acts in a prion-like way forming alpha-synuclein? >
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