In this #UTM Telegraft article, Andrés Caicedo Lab & Sebastian Penaherrera C present #mitochondria as a cell-free therapeutic option.
🔗isctglobal.org/telegrafthub/b…

Telegraft Andrés Caicedo Lab Sebastian Penaherrera C ISCT 🤔Why?🧐The simplicity of AMT/T contrasts with complexity of studying its potential #therapeutic effect based on the principle that damaged cells and tissues require #mitochondria to support phenotypic recovery via nanotubular structures and microvesicles.
pubmed.ncbi.nlm.nih.gov/33662580/

Telegraft Andrés Caicedo Lab Sebastian Penaherrera C ISCT 🤔What? 🧐 #Mitochondria enabled #evolution & #diversification of complex life forms, driving energy production and support cellular #signaling , #survival & #cellularcommunication , leading to development of artificial mitochondrial transfer/transplant (AMT/T)
pubmed.ncbi.nlm.nih.gov/37100996/

📢 #mitochondria as a #therapeutic option this month in the latest issue of ISCT Telegraft by Drs. Caicedo lab from Universidad San Francisco de Quito
🔗 isctglobal.org/telegrafthub/b…

Telegraft Andrés Caicedo Lab Sebastian Penaherrera C ISCT 🤔How?🧐 #Challenges exist in the GMP #scaleup #manufacturing of mitochondria from healthy tissues in accordance to #pharmaceutical #regulations . Advances in production of other AdvancedTherapies might help in the sourcing of viable & functonal mitochondria
pubmed.ncbi.nlm.nih.gov/32903493/

Telegraft Andrés Caicedo Lab Sebastian Penaherrera C ISCT 🤔Who?🧐There's no #commercial mitochondria preparations as #LivingDrug yet. However, the evidence that cells uptake #mitochondria from their surroundings or from other cells has spurred #interest in both in #academia and #industry .
pubmed.ncbi.nlm.nih.gov/38013162/

I am thrilled to have my video interview for the ISCT Telegraft Member Spotlight with Dr. Erja Kerkelä, Ph.D. out now! Enjoy this wonderful conversation with a fantastic researcher and champion of team science! youtu.be/k8XHLjlK_PY?si… via YouTube

My latest editorial on CAR-MSCs for the ISCT Telegraft - had a lot of fun writing this one! Check out the inspiration article from Saad kenderian linked within. Enjoy! #celltherapy

📢A recap of the ISCT panel discussion organised by Cambridge Healthtech Institute at #BioProcessing #Summit #Europe 2024 in Barcelona, Now #online on the Telegraft hub
✍️Dr. Anthony Ting #kijitherapeutics
🔗isctglobal.org/telegrafthub/b…

📢now online in the latest issue of the ISCT Telegraft ...a quiz #underthemicroscope 🔬
🧐 #UTM is a section introducing #cell types and cellular #products of #clinical interest. In the 2023 recap, Joaquim Vives invites Telegraft's readers
🔗isctglobal.org/telegrafthub/b…

📢Don't miss out this month's ISCT Telegraft issue including and #editorial by contributing editor Joaquim Vives on a common situation for scientists with young children planning to attend international conferences.
🔗isctglobal.org/telegrafthub/b…
🧵by Joaquim Vives ⬇️

📢Human #Pluripotent #Stem Cell-Derived #Pancreatic Islet Cells #underthemicroscope now #online in the latest issue of ISCT Telegraft
✍️Natasha Hui Jin Ng, PhD
✍️Adrian Kee Keong Teo, PhD
🔗isctglobal.org/telegrafthub/b…

🤔Why?🧐Type 1 #diabetes is a lifechanging, early onset disease (<20 yo). Patients require life-long insulin injections facing risk of complications even with compliance to treatment. Islet replacement therapy is a promising curative form of treatment.
🔗pubmed.ncbi.nlm.nih.gov/32627352/

Telegraft ISCT 🤔Who?🧐Companies @Viacyte and Vertex Pharmaceuticals have progressed their hPSC-derived pancreatic cells to first-in-human clinical trials. Recent news from Prof. Hongkui Deng's lab at Peking University reported initiation of early phase clinical trials for islet cells from hiPSC.
📷: Beatrice Ho

🤔How?🧐 #Source and #quality of the starting #cellbank are major factors affecting the cell manufacturing process. Another challenge relates to managing the immunogenicity of cells in allogeneic therapy.
🔗pubmed.ncbi.nlm.nih.gov/34349281/

ISCT Telegraft 🤔Did you know that… 🧐Primary human #pancreatic islets are known to contain 40-60% #betacells , 20-40% #alphacells , 5-15% #deltacells and a small abundance of other minor cell types (with cell composition differing across different individuals).
🔗isctglobal.org/telegrafthub/b…

Missed the ISCT North America Regional Meeting in Houston? Never fear. Check out this month’s Telegraft for the top takeaways from the amazing sessions organized by the Laboratory Practices Committee 📝 isctglobal.org/telegrafthub/b…

📢commentary article by Tuula Rintala on the JACIE Accreditation Strategic Plan 2023-26 now #online in the Telegraft
🔗isctglobal.org/telegrafthub/b…

#Pericytes #underthemicroscope by Valdor Lab now online!
🔗isctglobal.org/telegrafthub/b…
🧵x.com/xinoxan/status…

Showcasing the best ESP abstracts, hosting a panel discussion on mentoring with ISCT mentors! The #ANZ region of ISCT Early Stage Professionals Committee co-chaired by Madison Paton Jessica Sue (she/her) contributed greatly to #ISCTANZ regional meeting. Full story🔗👇 isctglobal.org/telegrafthub/b…