Online now! #Perspective ! Strategies of bacterial detection by inflammasomes by Jordan and Jonathan Kagan at Boston Children's Harvard Medical School Brigham and Women's Hospital dlvr.it/T5dcgd #chembiol

Meet the #CSChembio2024 organizers Michelle Arkin UC San Francisco, Nathanael Gray Stanford University, Mishtu Dey CellChemicalBiology, Zhaodong Li Cancer Cell, December 2-4, San Francisco, USA hubs.li/Q02t6XYD0

Online now! Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors by Andrew N. Dates, Stephen C. Blacklow, and colleagues at Harvard Medical School Harvard Med BCMP Dana-Farber dlvr.it/T5NScW #chembiol

Online Now! Grennady Wirjanata, Jianqing Lin, Julien Lescar, Zbynek Bozdech, et al at NTU Singapore screened clinically used anti-malarial drugs and identified the parasite aspartic protease, falcilysin, to be a common target. dlvr.it/T5F3Dp #chembiol

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer by Pfizer Inc. Shikhar Sharma, Thomas A. Paul, and colleagues CellChemicalBiology #AACR24 hubs.li/Q02rx7310

A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity buff.ly/3PQRrHr (CellChemicalBiology)

Want to know if your #cancerresearch fits within the scope of CellChemicalBiology. Feel free to book a meeting or DM me. #AACR24

Online now! A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity by Yeon-Jeong Kim, Ayako M. Watabe, Toshihisa Ohtsuka, and colleagues at 山梨大学 【公式】東京慈恵会医科大学医学部看護学科 dlvr.it/T57220 #chembiol

Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome: cell.com/cell-chemical-…

Have a question about publishing your #cancerresearch with CellChemicalBiology? Book a virtual meeting with scientific editor Samantha Nelson to hubs.li/Q02qCRqx0 #AACR24

Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1 by Seth Ludwig, Jamie Spangler SpanglerLab, and colleagues at Johns Hopkins University Johns Hopkins Kimmel Cancer Center University of Maryland School of Medicine Univ. of New Mexico Johns Hopkins ChemBE dlvr.it/T4j2df #chembiol

Congratulations to Seth, Pao, Ben, and team on their new multiparatopic downregulating antibody article in CellChemicalBiology! Huge thanks to our fantastic collaborators as well! Dr Helen Dooley Sridhar Nimmagadda
doi.org/10.1016/j.chem…

Mosher amides: not just for determining absolute stereochemistry

Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling by Keith Graham, Martin Lange, and colleagues at Bayer | Pharmaceuticals @Bayer #Nuvisan dlvr.it/T4fMSH #chembiol

CellChemicalBiology 30th anniversary Focus Issue on Bioorthogonal Approaches includes opinion pieces, reviews, and research articles highlighting specific approaches and insights that are key to addressing biological questions. hubs.li/Q02qh75C0

One-pot trimodal mapping of unmethylated, hydroxymethylated and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci by Kotryna Skardžiūtė, Kotryna Kvederavičiūtė, Edita Kriukienė, et al at Vilnius University dlvr.it/T4TFrd

HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson’s disease by Kulesskaya Natalia and colleagues at Neuro-Sys SAS, Herantis Pharma dlvr.it/T4TC0H

Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory by Eva Harde, Eoin C. O'Connor, Björn Bartels, Benjamin J. Hall, et al at Roche & more dlvr.it/T4T7bW

Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input by Ka Yang, Steven P. Gygi Gygi Lab, Qing Yu, et al at Harvard Medical School dlvr.it/T4T4TM

An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity by Haley N. Bridge, Amy Weeks, and colleagues at UW–Madison UW–MadisonChem UW–Madison Biochem dlvr.it/T4T0yF