'Pathways for macrophage uptake of cell-free circular RNAs'

Read more in Molecular Cell
cell.com/molecular-cell…

Stanford Medicine Howard Chang

Bidirectional epigenetic editing reveals hierarchies in gene regulation go.nature.com/4apFU9q

“Consensus changing” chemical biology at its finest, a new approach to modulating gene control. Neormorphic covalent ligands redirect the intently studied FOXA1 transcription factor, and instruct on pioneering functionality. A first TF-DNA glue? Way to go Michael Erb and Ben

Beautiful review article on ecDNA in Nature Reviews Cancer by Howard Chang Mischel Lab !!

🔥🔥👇🏻👇🏻
nature.com/articles/s4156…

Excited to share that our paper is out in Cell! We 'lnc' Xist ribonuceloproteins (RNPs) to the greater prevalence of autoimmune diseases in biological females.
A wonderful multi-institutional collaboration with Howard Chang and many others! cell.com/cell/fulltext/…

Delighted to be honored by the King Faisal Prize. I am deeply grateful for all my mentors, collaborators, supporters, and especially lab members former and present.
tinyurl.com/yssd6u8b

Very excited to see our paper with Doudna Lab Jimmie Ye Carl June Howard Chang Nadav Brandes out in Cell !! Obligatory tweet-orial (X-torial??) coming soon...

cell.com/cell/fulltext/…

Huge congrats to Jason Buenrostro, who was just named a MacArthur Fellow! Fantastic news!

So when does ecDNA arise, exactly?

Our study on #ecDNA and the transformation of pre-cancerous Barrett’s esophagus into cancer is out today. This collaboration brought together @Team_eDyNAmiC, Rebecca Fitzgerald Lab and the @FredHutch Seattle Barrett’s Study.🧵
nature.com/articles/s4158…

RIP Christopher T Walsh, a giant of chemical biology. Today Carolyn Bertozzi’s Cancer Breakthroughs seminar at Stanford is dedicated to Walsh and the profound ways in which he influenced and inspired us all.

Our work on ENTER is finally out Cell! Like📱that can 📷📞🎧, ENTER is a modular viral platform that unifies multiple applications:

⭐️Decode Ligand-Receptor interaction
⭐️Receptor-specific cargo delivery
⭐️Link receptor specificity with cell state at single cell

A modular, lentiviral-based display and delivery platform enables decoding of ligand-receptor interactions, receptor-specific genetic cargo delivery, and mapping of receptor specificity and cell states of single cells Howard Chang
cell.com/cell/fulltext/…

Happy to share that our work is online Molecular Cell. Our single-cell chromatin atlas of macrophage polarization reveals cyclical macrophage plasticity states in cell cycle. Great collaboration with Julia Belk, Howard Chang & Ansu Satpathy. cell.com/molecular-cell…

Thrilled to share our paper in Nature Genetics! Cancer cells often amplify oncogenes outside chromosomes. We can now isolate and profile these large circular extrachromosomal DNA (ecDNA) molecules using a method called CRISPR-CATCH. 1/10
nature.com/articles/s4158…

Congratulations to postdoctoral researcher Bingfei Yu for receiving a Parker Bridge Fellowship. bit.ly/3qLHSN4 Bingfei Yu Howard Chang Parker Institute for Cancer Immunotherapy The V Foundation

🤩OUT TODAY Nature Genetics
📰 The evolutionary dynamics of extrachromosomal DNA in human cancers
🧑🏿‍🤝‍🧑🏾 Mischel Lab WeiniHuang Cancer Grand Challenges @howardychang Benjamin Werner Anton Henssen
Jack Rose and team
👇🏾
go.nature.com/3RY2nSS

Our (awesome) Biology department at Stanford has an open position for an assistant professor. The deadline is Oct 31st. Please RT. facultypositions.stanford.edu/cw/en-us/job/4…

Reactivation of latent HHV-6 in CAR-T cells. Terrific work by Caleb Lareau in a close collaboration with many academic and industry colleagues. We hope this finding will help support the continued development of safe and effective cell therapies.

Immunotherapies are only as effective as their targets. Excited to share the launch of Cartography Bio, focused on finding safe and effective antigens for every cancer patient. Wonderful to work with founders Kevin Parker Howard Chang Maxwell Mumbach Caleb Lareau JeffreyVerboon

Thrilled to share a new paper from the Howard Chang lab in Nature Biotechnology, co-led with Robert Chen! We systematically engineer circular RNAs for stronger translation, boosting yields >200-fold and enabling potent and durable protein production in vivo 1/

nature.com/articles/s4158…