'A detailed look at tail-anchored membrane protein targeting – from opisthokonts to plants to protists”

So excited for today’s Current Biology Seminar! Dr. Bil Clemons (Clemons Lab @Caltech) is joining us from Caltech Chemistry & Chemical Engineering to share his latest research. Starts at noon in Pelton.

A key protein expressed in epithelial cells plays a critical role in protecting the structure and function of cells in the nervous system of a model nematode according to new research published by Cecilia Martin, Aakanksha Singhvi et al. in Developmental Cell. bit.ly/44k17Al

I'm excited to share our collaboration with Abdel-Wahab Lab Sergei Doulatov describing the RNA splicing factor GPATCH8, which plays a critical role in mis-splicing in MDS and leukemias with SF3B1 mutations! Led by Salima Benbarche Jose Mario Pineda Laura Baquero Galvis and just out in Molecular Cell

The 2024 @FredHutch Weintraub Graduate Student Award Symposium is this Friday (May 3rd)! We’re so excited to meet the amazing awardees and hear about their incredible research!
fredhutch.org/en/news/releas…

Mutant’s partner in crime could be target for future cancer therapy: Fred Hutch's Robert K. Bradley and Memorial Sloan Kettering Cancer Center scientists discover a new player and possible drug target in a critical biological process that’s skewed in tumors with certain mutations. bit.ly/3UmXCEQ

“3D chromatin structures in quiescence” and “targeted degradation of oncogenic drivers” – Friday Afternoon Seminars are going to be fascinating!

Don't miss talks from Rachel Dell in the Toshio Tsukiyama Lab and Saurav Kumar in Human Biology’s @BehnamNabet Lab. 4pm in Pelton!

It was a great pleasure to cover the work of Aakanksha Singhvi for the Fred Hutchinson Cancer Center this week on how nervous system cell shapes are influenced by a protein found in neighboring epithelial cells.
fredhutch.org/en/news/center…

Freie et al. show that a point mutation in MYC's phosphodegron domain affects MYC stability and function, resulting in aberrant self-renewal, apoptotic resistance & malignancy in hematopoietic progenitors.
Hutch Basic Sciences Fred Hutchinson Cancer Center

Read more here:
➡️tinyurl.com/gd351292

Paper out! We find that epithelia maintain glia-neuron properties under mechanical stress with animal age. A puzzle I started 12+ yrs ago got solved in my lab by Cecilia Martin and team Fred Hutchinson Cancer Center Hutch Basic Sciences 🧩🧬🪱🍾
Nice coverage by M. Nicole Nazzaro: bit.ly/44kKGnl

We're so grateful for our amazing research administrators. From keeping labs supplied, managing funding, and resolving problems big and small, @FredHutch Hutch Basic Sciences would not be a success without them. We're thankful for what they do every day. #AdministrativeProfessionalsDay

In new study led by Brendan Larsen in collab w The Veesler Lab VUMC Vaccine Center we map functional & antigenic landscape of Nipah virus receptor binding protein (RBP)
biorxiv.org/content/10.110…

Results elucidate constraints on RBP function & provide insight re protein’s evolutionary potential

📢 Join us this Friday, April 26, at 15:00 for the GenEvo-IMB Seminar with Prof. Dr. Harmit S. Malik at IMB Mainz Seminar Room (2nd floor).
#science #evolution #genetics #Seminar #HarmitMalik

David Sokolov from Fred Hutchinson Cancer Center Science Spotlight nicely summarizes Sneha Ray's work in the lab!
Specificity in glia-neuron interactions driven by glial cues localizing to micro-domains around individual neuron-contact sites. 👇🏽 and Cell Reports: bit.ly/44emwLl

'Protein monoaminylation: novel mechanisms of neural development, plasticity and disease'

We’re excited to have Dr. Ian Maze (The Maze Lab) joining us from Icahn School of Medicine at Mount Sinai for today’s Current Biology Seminar! For @FredHutch colleagues, don’t miss a great talk in Pelton at noon!

Special seminar today!
Dr. Seth Darst is joining us from Rockefeller University to share his research using cryo-EM to fill in gaps in the understanding of the bacterial transcription cycle. Starts at 10 am in B1-072/B074 (Weintraub B-Suites).

The best part of the week kicks off soon: Friday Afternoon Seminars!
Can’t wait to learn about the latest research from Lakshmi Mahendrawada in the Hahn Lab and Jackson P Fatherree in Human Biology’s DavidMacPherson. For all @FredHutch colleagues, join us in Pelton at 4PM for two great talks!

Such a pleasure to co-host Steve Liberles Harvard Med Cell Bio with Cecilia Moens at Hutch Basic Sciences! Got to hear exciting insights on vagus nerve biology (so much cool science!!), and have a super-fun dinner with Linda Buck and Jhimmy Talbot joining!

Join us at the 10th annual Health & Wellness Festival to celebrate Minority Health Month on April 20 from 11-3 PM.
Location: Rainier Beach Community Center, Seattle
There will be: Zumba, raffles, family activities, and a GIANT INFLATABLE COLON. bit.ly/4aCdHNT

“Mechanisms of body-brain communication”

For all our @FredHutch colleagues, don’t miss a fantastic Current Biology Seminar today at noon. We are incredibly excited to have Dr. Stephen Liberles joining us from Harvard Med Cell Bio to share his latest research.

Fun seminar visit to TAMU Genetics and Genomics comes to an end. Thanks to my student hosts Emmarie Alexander and Andres Barboza (such a privilege to be invited by trainees) & to my faculty colleagues for meeting me. For those wondering I’m wearing a t shirt featuring the blue genes and boots podcast.