【Human herpesvirus-6, HHV-8 and parvovirus B19 after allogeneic hematopoietic cell transplant】Curr Opin Infec Dis 2024 May 7

👉Important review article!

👉I really like Figure 1 and Table 1!

Erika Kampouri Jessica Little, MD Joshua Hill, MD

journals.lww.com/co-infectiousd…

Congrats to Dr. Diego Vargas & Olivia Hepworth and the wonderful team of clinicians and scientists. A shout-out to Mihalis Lionakis and Tobias Hohl MD, PhD and their team for working collaboratively on this project and their recent paper in Journal of Clinical Investigation on BTK and aspergillosis. (5/5)

Cytomegalovirus (CMV) Reactivation and CMV-Specific Cell-Mediated Immunity After Chimeric Antigen Receptor T-Cell Therapy

🔓 Open Access
bit.ly/3UOE6Co

Why do patients on Bruton's tyrosine kinase inhibitors develop aspergillosis?
BTK controls neutrophil p40-phox activation and Rac2-dependent 1 granule release in 🐭 & 👩👨. Collaboration with Mihalis Lionakis CramerLab + many others - Memorial Sloan Kettering Cancer Center
jci.org/articles/view/…

While the risk for the general population for H5N1 is low, transmission has been described - great to have this important case report of the first diary farm worker with HPAI H5N1.

nejm.org/doi/full/10.10…

Excited to present a case for Clinical Grand Rounds at ESCMID

Interesting cases & teaching points from all around the world 🌎

Sharing our work w/Emmanuel Dudoignon on fungal 🍄 infections in critically burned patients from Hôpital Saint-Louis AP-HP at #ESCMIDGlobal2024 !

#ECCMID2024 Hot topic 🔥 of developing AI tools for infection detection. Anna Khanina NCIC NCAS_Australia explaining the laborious manual process and aiming for AI detection. Check out this cool dashboard for fungal infections IFIS!!! Coming soon

Great #YECMM networking event last night under a giant 🍄 ! Thanks to all YECMM members who joined. To be renewed at #ESCMIDGlobal next year !

Rosanne Sprute Sarah Dellière Matthias Egger and ⬇️

#ECCMID2024 David Boulware, MD MPH trial Clinical Infectious Diseases on Oral Amphotericin B for Cryptococcal meningitis highlighted as a paper of the year shorturl.at/qxEH5 Look forward to seeing if this works at scale & for other Ampho indications

Do you think PET/CT scan is useful to follow up IFI? Future studies (coming soon!) will answer this question😎
#ESCMIDGlobal2024

Ben Teh reviews the drivers for really poor vaccination among immunocompromised patients - interventions that can reduce the morbidity and mortality of common infections - key is to do better ECCMID ESCMID

Excited to be in Barcelona for #ECCMID2024 with these #TxID stars Erika Kampouri and Anna Apostolopoulou, MD

#womeninID

Amazing work by Anna Apostolopoulou, MD - will we see ICI as adjunctive therapy for fungal infections in the future?

#TxID #ECCMID2024

PTCy as #GvHD prophylaxis has significantly improved outcomes following haploidentical transplant.

Watch our interview w/ Rémy Duléry (@HopSaintAntoine) to learn about side effects, dose optimization, & the effect of dose reduction:
ow.ly/ksSV50Riewu

The EBMT #BMTsm

🚨Pioneering work on HHV-6B by Joshua Hill, MD in HCT and CAR-T settings. Thanks for moving the field forward! #bmtsm #CARTcell #HHV6 🦠 Erika Kampouri ASTCT Blood Journal Nature Communications Michael Ison, MD MS Dr Roy Chemaly Jessica Little, MD

nature.com/articles/s4146…

ashpublications.org/blood/article/…

Next stellar paper by Erika Kampouri and Joshua Hill, MD from Fred Hutchinson Cancer Center out in Blood Journal ⤵️

In a nutshell:

“Our data demonstrate that HHV-6B reactivation and disease are infrequent after CARTx. Routine HHV-6 monitoring is not warranted.”

ashpublications.org/blood/article/…

#EBMT24
Outstanding talk by Leslie Kean showing a bottle-neck effect for TCR diversity after PTCy and providing a mechanistic explanation for both the efficacy as well as the immunologic and infectious disease trade-offs associated with PTCy.

A well-deserved Van Bekkum award👏🏻

Congrats to an incredible mentor, brilliant scientist and just one of the most inspiring individuals out there! Joshua Hill, MD
Well deserved just doesn’t cut it! ICHS-Global @FredHutch @HutchID University of Washington