Local environment in biomolecular condensates modulates enzymatic activity across length scales | Nature Communications nature.com/articles/s4146…

New research from Robert Horne KnowlesLab Cambridge Vendruscolo Lab & colleagues presents a machine learning approach to identify small molecule inhibitors of α-synuclein aggregation, a process implicated in #Parkinsons & other synucleinopathies
nature.com/articles/s4158…

🔹Helicure: cap una nova #teràpia per la malaltia de #Parkinson .

Projecte concedit dins de la modalitat LLAVOR i liderat per Irantzu Pallarès, del grup de recerca Plegament de Proteïnes i Malalties Conformacionals.
Ventura's Lab

🔹NanoGlue: Unions moleculars de nova generació per a neutralització #viral .

Projecte concedit dins de la modalitat INNOVADORS i liderat per Salvador Ventura del grup Plegament de Proteïnes i Malalties Conformacionals.
Jordi Pujols serà l'innovador involucrat.
Ventura's Lab

Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions | Nature Communications nature.com/articles/s4146…

Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease | Nature Medicine nature.com/articles/s4159…

Saying goodbye to Guangzhou, China, after the wonderful 2024 International Neural Regeneration Symposium Neural Regeneration Research-Journal

The 2024 International Neural Regeneration Symposium Neural Regeneration Research-Journal in Guangzhou, China arrived to an end.
We enjoyed it a lot!!!

FrustraEvo, to calculate local frustration conservation in protein families, is out at Nucleic Acids Res Web Server Issue 2024 doi.org/10.1093/nar/gk…
Great work w/ Maria Freiberger, Miriam Poley, Miguel Fernández, Leandro Radusky, Victoria Ruiz, Peter Wolynes, full sarasa💛 & AlfonsoValencia [email protected]!

Happy and super excited to share our discovery of a protein fractal! We unravel the surprisingly simple emergence of these marvellous structures and show it might have even been an accident of evolution. Read the full story here

nature.com/articles/s4158…

Or just stick around 🧵

Ready to speak about #Protein Aggregation at the 2024 International Neural Regeneration Symposium Neural Regeneration Research-Journal in Guangzhou, China

Already at the 2024 International Neural Regeneration Symposium Neural Regeneration Research-Journal in Guangzhou, China

🎉 We're excited to announce Prof. Dr. Salvador Ventura as a keynote speaker for #IECBM2024 !

🗓️ Join us virtually from April 23-25, 2024. Register by April 17th to secure your spot!

🎟️ Register here: sciforum.net/event/iecbm202…

#Biomolecules #Conference

Antibody therapy makes the immune systems of old mice young again | New Scientist newscientist.com/article/242440…

MarieSkłodowskaCurie can Americans apply?

New cover: 🔬Cryo-EM and Amyloids🌀

Trends in Biochemical Sciences
'The aberrant accumulation of amyloid structures is the underlying cause of severe human diseases. However, the amyloid fold also plays a role in executing specific biological functions. Javier Garcia-Pardo Ventura's Lab discuss how the

New paper from the lab: Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Congratulations to to all of those involved and thanks to Aligning Science Across Parkinson’s and CIHR for the support. uOBMRI uOttawa | Faculté de médecine, Faculty of Medicine

nature.com/articles/s4141…

Architecture and regulation of filamentous human cystathionine beta-synthase | Nature Communications nature.com/articles/s4146…

Last article out! We developed a plasmonic biosensor for specific detection of α-synuclein toxic oligomers in biofluids as a strategy for early diagnosis of #Parkinson . By Jaime and Irantzu Pallarès in a nice collaboration with Laura M. Lechuga Gom lab!

sciencedirect.com/science/articl…

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation: Cell embargoed.www.cell.com/cell/fulltext/…