We are hiring! The PataniLab is looking for a bioinformatician to work on an exciting project on RNA metabolism and DNA damage in ALS funded by My Name'5 Doddie Foundation, all detalis here: ucl.ac.uk/work-at-ucl/se… still a few days left to apply!

APP antisense oligonucleotides reduce Aβ aggregation and rescue endolysosomal dysfunction in induced pluripotent stem cells derived from people with Alzheimer disease academic.oup.com/brain/advance-…

'There is an urgent and unmet need for discovery of disease mechanisms in ALS in order to inform new treatment strategies. Our study is a powerful example of how interdisciplinarity and team science can catalyse such discoveries.' - PataniLab

More ⬇️ bit.ly/48qwASn

Also massive thanks to The Lister Institute of Preventive Medicine that supports both myself and Rickie Patani and brought us together, playing a massive role in this study!

Thank you Hayley Dunning for covering our recent Nature Communications paper on RNA-mediated aggregation in ALS, work led by the amazing Federica Raguseo and in collaboration with the great DiMicheleLAB, Rickie Patani Francesco A. Aprile and Yuval Elani imperial.ac.uk/news/250293/un…

We're thrilled that collaboration between our #ListerFellows Di Antonio Research Group and PataniLab has contributed to this Nature Communications paper on the role of unusual RNA in #ALS . Congratulations to all involved 🧑‍🔬🎉🧬🎓 nature.com/articles/s4146…

We're so pleased to be able to bring great minds together Di Antonio Research Group Rickie Patani

Unravelling what goes wrong in #MND is key to creating a world free of MND.

PataniLab are investigating whether DNA damage plays a role in MND development and progression.

MND Association is proud to fund research which could pave the way to explore new potential therapies.

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It’s Dr Neuroblonde now! 👩‍⚕️Yesterday I successfully defended my PhD! 🎓 Immense gratitude to my incredible examiners Prof Selina Wray and Dr Ox for their insightful questions and making the Viva so enjoyable. Thank you PataniLab UCL Birkbeck MRC DTP. Let the next chapter begin!

Thrilled and incredibly grateful to have recently started a 3 year MND biomedical research project grant from the MND Association I was awarded with Rickie Patani to continue investigating the mechanisms of glial dysfunction in MND. 🧪🧠🧑‍🔬PataniLab MND Research

I am thrilled to share that my first author paper from the PhD in the Di Antonio Research Group is finally out! I am incredibly thankful to all my collaborators without whom this work could have not been possible! Francesco A. Aprile PataniLab DiMicheleLAB

nature.com/articles/s4146…

Our latest Brain: Elevated 4R tau drives neurodegeneration in VCP-related frontotemporal dementia. Link: academic.oup.com/brain/advance-…
Led by the very talented Dr Christy Hung (currently applying for faculty positions!) @Patanilab Medical Research Council UCL Queen Square Institute of Neurology MND Association My Name'5 Doddie Foundation The Crick

Finally, and most importantly, this work is the result of a multi-collaborative effort and it could have not been possible without the amazing DiMicheleLAB, PataniLab, Francesco A. Aprile and Yuval Elani. Thank you all for your support!

In this context we demonstrated how formation of intermolecular G4s can trigger aggregation of RNA expansion repeats that are typical of ALS/FTD, further highlighting the biological impact that the formation of these structures can have in regulating cell homeostasis.

I am very happy to share our latest article now out in Nature Communications. This work led by Federica Raguseo demonstrates how the formation of solid aggregates in neurodegenerative diseases can be elicited by RNA aggregation mediated by G-G base pairing 👇👇👇
nature.com/articles/s4146…

Thrilled to share this Nature Communications by Federica Raguseo showing that the C9orf72 6nt repeat (GGGGCC)n, relevant for ALS/FTD, forms condensates mediated by G4. Great collaboration Di Antonio Research Group PataniLab Yuval Elani Francesco A. Aprile
nature.com/articles/s4146…

Huge congratulations to Giulia Tyzack for her recent promotion to Senior Research Fellow UCL Queen Square Institute of Neurology and for leading a major grant from the My Name'5 Doddie Foundation addressing the link between DNA damage and ALS pathogenesis PataniLab Medical Research Council MND Association The Crick ucl.ac.uk/ion/news/2023/…

A productive session at our Scientific Advisory Meeting today 🔬

We regularly bring together leading MND researchers, along with people affected by MND, to encourage collaboration & knowledge sharing. This helps to inform how we implement our research strategy & activities 🤝

Our latest Trends in Neurosciences reviews an important mRNA surveillance pathway (NMD) in neuronal physiology and neurodegeneration: sciencedirect.com/science/articl… A pleasure to write this with the talented Marija Petrić Howe PataniLab UCL Queen Square Institute of Neurology MND Association The Lister Institute of Preventive Medicine Medical Research Council The Crick