Delighted to share one of the last projects from fellowship with wonderful collaborators and mentors ⁦Fergus Keane⁩ ⁦Rona Yaeger⁩ ⁦Walid Chatila⁩ ⁦Henry Walch⁩ aacrjournals.org/clincancerres/…

Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention pubmed.ncbi.nlm.nih.gov/38244726/

Dr. T Andre presents the initial results of the phase III Checkmate 8HW of Nivo/Ipi vs. chemotherapy for stage IV MSI-High/dMMR #colorectal #cancer with a splay in KM curves for PFS at 3M. Look forward to combo vs. single IO results. #GI24 ASCO #CancerResearch #immunotherapy

In MSI high mCRC Ipi Nivo was dramatically superior to chemo first line with marked improved PFS. Results of Nivo alone awaited. Establishes a new first line option in MSI high mCRC.

Young onset #PDAC ⬆️frequency

🟢⬆️importance modifiable risk factors (smoking, alcohol, obesity)
🟠Role of Pub-health
🟢⬇️KRAS mutations
🟢⬆️targetable alterations
🟢?Better outcome

Excellent keynote Kimmie Ng, MD, MPH #GI24
pubmed.ncbi.nlm.nih.gov/36068272/
'CRC the canary in the coalmine!'

‼️ Rise in young onset GI cancers! #GI24
➡️ #CRC leading cause of cancer death in men & 2nd in women
➡️many reasons -lots unknown
➡️rise in #PancreaticCancer #livercancer
➡️Pt needs different eg fertility
➡️Profiling imp in all inc PDAC 👇Erica Tsang
👏 fab talk Kimmie Ng, MD, MPH

The oncology community globally recognises that #clinicaltrials are central to high quality cancer care.

Grainne O'Kane from Trinity St James's Cancer Institute updates the CancerTrialsIreland 🌈 study day that #Ireland has the fastest growth in trial recruitment in #Europe

Young-onset #pancreaticcancer rising globally (GBD data). Smoking, tobacco, obesity & high glucose- regional risk factors. Need for action! Flinders University Cedars-Sinai Uni of Adelaide Flinders UniversityHMRI Flinders UniversityUniNews Anirban Maitra Syed A. Ahmad sciencedirect.com/science/articl…

Amazing and super that pancreas cancer is in the #1 pole position for most cited article ever in Journal of Clinical Oncology - it was fun to write this commentary with @AndrewKo and esteemed Editor in Chief Jonathan Friedberg

Irish Cancer stats published this wk
➡️pancreas ca has lowest overall 5yr survival 14%
➡️47% present at stage IV
➡️primary liver cancer 2nd lowest overall survival 18%
➡️pancreas cancer 2nd most common cancer to present as an emergency Pancreatic Cancer Ireland Tom Gallagher Grainne O'Kane

#HPB Commemoration Pancreas Symposium 23’ Memorial Sloan Kettering Cancer Center MSKCC Center for Pancreatic Cancer Research

👫 #Team 🧬🧪🥼 #Science & #Patient #Care Learning from the top experts in the field!

Chris Iacobuzio Eileen M O’Reilly Vinod BalachandranMD Alice Wei Marsha Reyngold Drs. Ken Yu. Richard Do. MSK CME

Looking forward to a great group joining Johns Hopkins Medicine in July. Including Dr. Rachel J Keogh from Ireland 🇮🇪 Royal College of Physicians of Ireland CancerTrialsIreland 🌈 All-Island Cancer Research Institute (AICRI)

And here's the poster with the second part of our STTR2 transcriptomic work, this time in Nasopharyngeal Carcinoma, with Caris Life Sciences and Dara Bracken-Clarke from NCI CCR Med Onc Service and Society for Immunotherapy of Cancer IO fellowship! #HNC

Are u a patient, or survivor of #ColoreactalCancer ? Or was/are a caregiver 4 a #CRC #patient ? We need u! Deets ⬇️ Plz 🔄 ❤
Oana Deac ARC Cancer Support Purple House Cancer Centre Alison O'Connor Stephen Bradley 𝗔𝗺𝘆 𝗡𝗼𝗹𝗮𝗻 💛 @sineadboolynch Siobhan Gaynor Roisin Riches Audrey O'Halloran

#BiliaryTractCancer is a rare disease with poor prognosis. GemCisDurva is a new standard Tx #TOPAZ1 No definitive markers for response and resistance. Seeking immune exclusion markers from diff cells (AOI) at diff regions (ROI) by spatial transcriptomics #SITC23 Eileen M O’Reilly

This year’s Gathering Around Cancer will be one of the highlights of the cancer conference calendar CancerGathering John McCaffrey Megan Greally Irish Cancer Society NCCP National Cancer Registry Ireland CancerTrialsIreland 🌈 Mark Robson

#cancer #cancer research #oncology

ow.ly/1CwG50Q0xbm

Nice summary of areas for research opportunities in #HCC While prevention should be goal, avoiding transition to CP B dysfunction also has to be targeted more Grainne O'Kane Lorenza Rimassa Bristi Basu Arndt Vogel Derek O'Reilly

#TumorBoardTuesday Patrick Forde Mike Pishvaian Johnathan Ebben MD, PhD Narjust Florez, MD, FASCO Dipesh Uprety MD FACP Christine Lovly, MD, PhD Eric K. Singhi, MD Amir Safavi Jarushka Naidoo Emer Hanrahan Jonathan Friedberg Gerard ZALCMAN Samuel Kareff, MD, MPH Nathan A. Pennell MD, PhD, FASCO Lecia Sequist, MD, MPH Charu Aggarwal, MD, MPH, FASCO Ana I. Velázquez Mañana, MD MSc (she/her/ella) Brendon Stiles Rami Manochakian MD, FASCO 🇺🇸🇸🇾CancerEducation Geoff Oxnard MD Devika Das, MD, MSHQS Benjamin Levy Harpreet Singh, MD Lauren Averett Byers, MD Johns Hopkins Thoracic Oncology Aaron Mansfield Heather Wakelee Dave Bjork Joshua Reuss Yvonne Diaz Ben Solomon Dr. Amy C. Moore Jacob sands Jacob J. Adashek, DO Jill Feldman TerriConneran LUNGevity Foundation Amanda Nerstad Summer Farmen Vincent Lam Meena Thakur じん Roy Herbst Hossein Borghaei, DO H. Jack West, MD Pat Adams Sanjay Mukhopadhyay IFCT lung 23/23 #TumorBoardTuesday
💫Recap💫

📍Pleural mesothelioma is rare
🙌🏽Significant advances in last 3yrs
📍Full staging + path rv essential to optimize tx
🔪Surgical role limited & evolving
📍Ipi + Nivo: 1st choice, especially in non-epithelioid histology
🔮Need MORE research!!

☘️ #ESMO23 developments + updates on #Mesothelioma treatments are perfect timing for this week’s #TumorBoardTuesday !

🇮🇪Patrick Forde Sarah E. Lochrin are teaming up & putting finishing touches on their #LungCancer case

🫁Join us 10/24 at 8pm ET here!
#CME integrityce.com/TBT2023👈🏼

Anyone following #esmo23 virtually or any insomniacs like myself, please join the outstanding Dr. Sarah E. Lochrin (& me, both from 🇮🇪!) as we discuss #mesothelioma in a tumor board format this Tuesday night 8pm US Eastern time (1-2am Wed Western Europe, 9am wed Aus/Asia). Mesothelioma Applied Research Foundation