What Marc meant to say is that acute infection of lymphoid tissue leads to durable immune memory. What Marc doesn’t know is that SARS2 antigen persists in bone marrow indefinitely unlike MeV in macaques(21 days) impairing PBMCs and hematopoiesis by persistently activating CD8+

Now out in JAMA Network Open , Art Schuermans and I w/ Alex Reiner Fred Hutchinson Cancer Center examine the role of clonal hematopoiesis of indeterminate potential (CHIP) 🩸🧬 in future/incident development of heart failure and its subtypes (HFpEF and HFrEF)

jamanetwork.com/journals/jaman…

👇

(1/X)

Thank you Dr. Ashley Kamimae-Lanning Ashley Kamimae-Lanning from MRC WIMM for visiting us Nutritional Sciences at Cornell Cornell Human Ecology Cornell CALS. Excited to hear her work on aldehydes shaping early hematopoiesis. Both of us are progenies of KJ Patel CAM-OX traveller lab, now taking aldehydes in new directions!

Happy to share our new paper published in JACC Journals on the Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality. sciencedirect.com/science/articl…

🔥 story lead by Michael Scherer & Indranil Singh, with Alejo Rodriguez-Fraticelli, PhD: epimutations stably mark clones in hematopoiesis over months and years, and can be read out at scale using targeted single-cell, single-CpG-resolution profiling of DNA methylation🧵biorxiv.org/content/10.110…

Myelodysplastic Syndrome - group of disorders caused by poorly formed or dysfunctional blood cells, often characterized by hypercellular marrow with ineffective hematopoiesis in all lineages (RBC, WBC & platelets)

💥 CYTOKINES 💥

IL-1 — fever
IL-2 — t cell and b cell growth factor
IL-3 — promotes hematopoiesis [all lineage]
IL-6 — APR & renal stone marker

Wondering how microRNAs can have mighty impacts on the transcriptome?
Here (rdcu.be/dHdub) we show how miR-144 effects expand beyond its direct targets by targeting a chromatin regulator during hematopoiesis. Congratulations, team!

Congrats to Esra Gumuser MGH Cardiology Fellows Art Schuermans KU Leuven whose paper on clonal hematopoiesis 🩸 🧬 and recurrent ASCVD 🫀 events was selected by Dr. Fuster as a JACC Journals #JACC 2023 editor’s top pick! Paper: jacc.org/doi/10.1016/j.…

Engaging crowd as Nathan Chen and Jennifer Kwan MD PhD show their data that clonal hematopoiesis of indeterminate potential is a risk factor for ICI myocarditis at #ACC24 Nona Jiang, MD, SM Debbie Lin Teodorescu MD/MEng/AM Mandana Chitsazan, M.D. Sara Diaz Saravia MD

Air pollution is a recently recognized driver of lung cancer among never-smokers.

In a new preprint, we show that clonal hematopoiesis of indeterminate potential (CHIP) and PM2.5 form a novel gene × environment interaction promoting NSCLC tumorigenesis.

medrxiv.org/content/10.110…

#hemepath CD34 IHC highlighting intravascular hematopoiesis in an MPN

Natural History of Clonal Hematopoiesis Seen in Real-World Hematology Settings
buff.ly/4cvNd1M
Shyam Patel
Jan Cerny, MD, PhD
Muthalagu Ramanathan

🔮nice talk by George Vassilious about clonal hematopoiesis. Few mutant genes with different fitness related to age. TP53 is frequent but had slowly growing. TET2 seems more frequent in older patients…so, what else? #CETLAM2024 Grupo CETLAM

#clonal #hematopoiesis of #indeterminate #potential ( #CHIP ) associates with a higher risk for #CAD and #MI early in life!
#EASCongress2024
EAS Congress European Atherosclerosis Society

📢 Very happy to share our latest paper Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis, just published in Cancer Discovery

Explore our findings here: aacrjournals.org/cancerdiscover… 🩸🧬💻

Pre-gaming for the clonal hematopoiesis education session tomorrow! #AACR2024 #AACR24

Great chat with Grant (Grant Rowe) and Vijay (@bloodgenes) at Boston Children's! Thanks for discussing mitochondrial regulation in adult and developmental hematopoiesis and experimental hematology Elsevier Hematology. Excited for collaborations! See you at ISEH in Chicago!

Find out more on how clonal hematopoiesis affects cardiac fibrosis this week in Nature Communication. Thanks to an incredible team lead by Mariana Shumliakivska 🇺🇦 and Guillermo Luxán and all the collaborators! 😀

#NewPI in hematopoiesis!? Check out the Junior Faculty Grant Writing Workshop, a premeeting ISEH annual meeting #ISEH24 ! Pricing is way lower than comparable offerings, and the instruction and personalized feedback is invaluable! #ScienceIsInOurBlood