Really chuffed to share our latest work from Sanjana Lab out in @nature today (nature.com/articles/s4158…).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies .

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Breaking: Includes a truly inspiring commission from the brilliant mind (and hands) of Alex Cagan! 🙏😍🙏

#OpenScience #OpenAccess

New! Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens
👉Resource open access, enables guide RNA design for custom RNA targets 👏
Neville Sanjana Cathy Guo Jahan @we_harm alexmenman NY Genome Center New York University NYU Grossman School of Medicine

Delighted to see this work from our lab is now published as the first-ever (!) article in Cell Genomics:
cell.com/xgen/newarticl…
cell.com/cell-genomics/…

Congrats to PhD student Cathy Guo & many other lab members. Check out our previous tweetorial for an overview 👇

Preprint alert! 🚨 New work from our group for transcriptome engineering in human cells — including in T cells & to target SARS-CoV-2 — using chemically-modified guides and Cas13 RNPs.

Postdocs alexmenman & @we_harm led the work & here's a great summary from Alex:
👇👇👇

Delighted to share work from my postdoc, co-advised by Neville Sanjana and Tuuli Lappalainen! It began with wanting to identify target genes for GWAS with CRISPR screens and single-cell seq. Brief look below, with shout-outs to my amazing co-authors!

Link: biorxiv.org/content/10.110…

New preprint from our group: “Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens” led by Cathy Guo with big help from @we_harm, alexmenman and #DanHaro .

biorxiv.org/content/10.110…

“...as U.S.-China tensions worsen, I am left wondering what will come next.” And today the US government decide to ban WeChat. An app I used on a daily basis since I came to the US 8 years ago, the app that connect us to our friends and families back home. science.sciencemag.org/content/369/65…

Trump’s executive orders against WeChat and TikTok are yet another abuse of emergency powers under the broad guise of national security. They would violate the First Amendment rights of users in the US who use these apps to communicate with family, friends, or business contacts.

It is not well appreciated, but the truth is that one never really finishes to analyze a dataset. You just decide to stop and move on at some point, leaving some things undiscovered.

Four labs (C. Gao, J. Keith Joung , D. Li, yachielab) report combining cytosine base editors (which convert C•G to T•A) & adenine base editors (which convert A•T to G•C) into combination base editors that make both conversions, especially useful for screening & evolution. 1/2

Excited to share this preprint from the Neville Sanjana lab, led by myself and an ultratalented NYU undergrad, Jahan Rahman (@jahanpehechanho). We designed CRISPR prime editing reagents to target thousands of human pathogenic variants. Key findings 1st! 👇
biorxiv.org/content/10.110…

We are pleased to announce new Hi-C heatmap tracks for hg19 and hg38. This is part of our ongoing support for researchers studying the structural components of gene regulation.
genome.ucsc.edu/goldenPath/new…

A quantum computer solves a problem in 200s that not possible on the fastest supercomputers. 😮

Neuralink unveiled a sewing machine-like robot that will implant ultrafine flexible electrodes deep into the brain. But what is it *for*? trib.al/NDC9LZv

We've released a preprint with additional scientific detail on our devices for domain experts who want to know more. You can find it on bioArxiv: 'An integrated brain-machine interface platform with thousands of channels' biorxiv.org/content/10.110…

Huge progress in neuroscience. We are getting so much better at neural decoding. It has been more than a decade since the first visual decoding work so great to see this leap forward.

TARGET-seq is out in Molecular Cell ! Like moving from a blury photograph to a high resolution picture of #cancer we can now perform parallel mutation and whole transcriptome analysis from the same #SingleCell cell with extremely high resolution. cell.com/molecular-cell…

This is an important study. Well worth the read if doing CRISPR screens

Using a stringent filtering tool called LOFTEE github.com/konradjk/loftee, we identify ~443K predicted loss-of-function variants, and 1,752 genes where we find at least one biallelic knockout individual (2/5).