At Biology of Genomes #bog24 ?

Don't miss Wen-Wei Liang's talk TONIGHT on Transcriptome-scale screens w/ RNA-targeting CRISPRs — joint work from her & Simon Müller in our lab.

Exciting new approaches to identify functional noncoding RNAs across the human transcriptome!
🕵️✂️

Congrats to Mat Legut, PhD & the entire OverT Bio team! Grateful for the opportunity to translate discoveries from our lab NY Genome Center & New York University into therapies for cancer patients.

Thrilled to be a part of this amazing team — onward and upward! 🚀

Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens
hubs.li/Q02v7f8z0
Neville Sanjana Cathy Guo Jahan @we_harm alexmenman NY Genome Center New York University NYU Grossman School of Medicine
Up-and-coming genomics research from Cell Genomics #CRISPR

Two preprints from my lab: (2) we developed a dataset and task independent metric to evaluate distribution shifts in federated learning, it can be calculated in privacy-preserving manner, and it predicts the performance of FL without the need for training: arxiv.org/pdf/2404.18773

Two preprints from my lab: (1) we developed an encrypted genotype-phenotype database query/analysis mechanism that allow multiple parties to interact with it through a framework we call public key switching: biorxiv.org/content/10.110…

How about combining single-cell and spatial transcriptomics to study tissue and cellular spatiotemporal dynamics in colon aging?
Aidan Daly, Francesco Cambuli, Richard Bonneau, Aviv Regev, and I are happy to share our latest pre-print (1/16):
biorxiv.org/content/10.110…

I'm so excited to be on my way to National Cancer Institute tomorrow, to be a keynote speaker for the DCEG Fellows meeting, GENETHICS. (Following the amazing Dr. Kimryn Rathmell, Dr W. Kimryn Rathmell, will be tough, though.) Extremely grateful for the opportunity!

How much joy can single-cell RNA-sequencing impart? Plenty, say Teichlab Wellcome Sanger Institute Cole Trapnell Rahul Satija NY Genome Center, Yuhan Hao, Kasper Hansen Johns Hopkins Bloomberg School of Public Health and others.
nature.com/articles/s4159…

We’re delighted that Dennis Yuan (Postdoctoral Fellow, @NYGenome) will be speaking at The Festival of Genomics and Biodata in Boston this June! There’s still time to get your ticket, register now: hubs.la/Q02tXvxT0 #FOGBoston

VIRTUAL Neuroscience Lecture taking place tonight! Please register using the link below if you would like to attend. We hope to see you there!

We're recruiting postdocs! Join our lab at
SciLifeLab KTH Royal Institute of Technology in Stockholm to work on functional genomics at the experimental and/or computational intersection of CRISPR/scRNA-seq/genetics approaches. Close links to our team at
NY Genome Center. 1/

A study led by Dr. Anoushka Joglekar, a postdoctoral researcher at grantee NY Genome Center, assembled the most comprehensive atlas of messenger RNA, which will aid in understanding brain development, neuron specialization and other brain functions. news.weill.cornell.edu/news/2024/04/n…

My overview talk from Single Cell Genomics Day 2024, covering our favorite new technologies and computational methods for the single-cell/spatial field, is now online at
youtube.com/watch?v=eQ7wzm…

(thanks @ATCCagan for the live illustration!)

Join us on our At the Lab podcast as we delve into CSHL's groundbreaking research on autism’s origins during #AutismAwarenessMonth in under 3 minutes! 🧬 cshl.edu/podcasts/at-th…

JOIN US Monday, April 22 @ 5PM for a VIRTUAL Neuroscience Lecture moderated by Thomas Lehner, PhD, MPH, with speaker Paola Arlotta, PhD, on “Human Brain Organoids as Avatars to Study Development and Disease of the Human Brain.”
Register Here: bit.ly/43WPzD5

Our first #ToolsoftheTrade article has just been published go.nature.com/3VWmju4
Dongsheng Bai (Dongsheng Bai) and Chenxu Zhu (@chenxuzhu) NY Genome Center wrote about SIMPLE-seq to decode DNA methylation dynamics in single cells (based on their Nature Biotechnology paper with Chengqi Yi)

New preprint 🎉 led by Philipp Rentzsch 👇! We introduce an approach to prioritize biological driver genes by recalibrating differential expression fold changes with population variance. This extracts new meaning out of DE analysis, which is a cornerstone of computational biology!

See #CancerGrandChallenges and our five new teams in the April issue of Cancer Discovery ⤵️

You can learn more about the new teams as well as the impact our first set of funded teams have made against their challenges at #AACR24 stand 1313.

aacrjournals.org/cancerdiscover…

Our next Center for Integrated Cellular Analysis Virtual Seminar (12PM on 4/16)

Carol Dalgarno & Longda Jiang use Perturb-seq+Parse Biosciences+Ultima Genomics to perturb signaling regulators across cell lines & infer causal regulatory changes from scRNA-seq/spatial data.

Free registration: nygenome.zoom.us/meeting/regist…

Michael Zody, PhD, Scientific Director of Computational Biology at NY Genome Center, is part of a Cold Spring Harbor Laboratory team recently awarded $2M from the U.S. National Science Foundation. The new project seeks to find solutions at the intersection of genomics and plant biology.

Read more here: bit.ly/3PPScki