An inspiring meeting on #MDSsm with ⁦Sanam Loghavi, MD صنم لغوی 🔬🧬⁩ ⁦@olsneskittang⁩ ⁦Shahram Kordasti⁩ Stay tuned for #immunology news… good things happening here. #london

Our study on clonal evolution in Fanconi anemia is out in Cell Stem Cell. In the FA background of chromosomal instability & HSC attrition, trisomy 1q/MDM4-driven p53 downregulation yields clonal hematopoiesis, preceding sAML.
authors.elsevier.com/a/1gX1h6tu0Cm4…
#BMFsm #leusm #mdssm #AMLsm 1/2

Cardiac effects of deferasirox in transfusion-dependent patients with myelodysplastic syndromes: the TELESTO study onlinelibrary.wiley.com/doi/10.1111/bj… #mdssm #leusm

Portrait unveiling at the conclusion of the John F DiPersio Immunotherapy Symposium
WashUOncology Siteman Cancer Center WUSM Department of Medicine Washington U. Med Barnes-Jewish Washington U. DBBS WU Division of Physician-Scientists
#bmtsm #celltherapy #cartcells #leusm #lymsm #mmsm #mdssm

✅Changes in IPSS-R between dx & HSCT did not affect HSCT outcome if no prior therapy was applied.
✅Downstaging IPSS-R by chemotherapy improved HSCT outcome.
#MDSsm #BMTsm Blood Journal DrDonalMcLornan The EBMT Trainee Committee
doi.org/10.1182/blood.…

Excellent international collaboration led by GenoMed4All # Dr. Della Porta on using IPSS-M Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Myelodysplastic Syndromes #MDSsm | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…

Had the opportunity to discuss what we have learned about immune targets in MDS at #MDS2023 #mdssm

Which #MDSsm patients are most likely to have UBA1 mutations associated with #VEXAS syndrome?

Our study now out in Blood Journal: Molecular and clinical presentation of UBA1-mutated MDS by Elli Papaemmanuil, PhD, Elsa Bernard, Maria Creignou, David Beck, MDS IWG-PM & MDS Foundation

Practice-changing results at #EHA2023 Plenary session:
Luspatercept moves into 1st line for transfusion-dependent low-risk MDS!
Superior transfusion independence compared to Epoetin alfa!
Important step for patients!
@ matteodellaporta G Garcia-Manero MDS Foundation
#MDSsm

Our perspectives NIH Fred Hutchinson Cancer Center Stanford Medicine in Blood Journal on
How I reduce and treat posttransplant relapse of #MDSsm ashpublications.org/blood/article-…

Finally out in AmericanJournalofHematology!
In adults with :
1⃣hypereosinophilic syndromes AND
2⃣“myeloid” features (splenomegaly, ⇑ tryptase, other CBC abnormality, corticoR) AND
3⃣lacking tyrosine kinase fusions
👉>50 % have mutations in the JAK-STAT pathway
#MDSsm #MPNsm #leusm #CEREO

Who was your childhood/teenage years science hero? Carl Sagan here! (& didn’t choose to work on #MDSsm because he died from it, just a coincidence)…

Excited to be at this MDS Workshop National Cancer Institute! Addressing the challenges and needs in MDS clinical, basic and transitional research. Great overview opening talk by G Garcia-Manero! #leusm #MDSsm #hematology

Great morning talks National Cancer Institute MDS Workshop from Amer Zeidan MBBS,MHS ‏عامر زيدان Monica Guzman Lukas’s Gondek Brett Stevens and Russel Rockne. Next session on Genetic Predisposition led by Dr. Lucy Godley! #leusm #MDSsm #Hematology

Venetoclax plus hypomethylating agents in DDX41-mutated acute myeloid leukaemia and myelodysplastic syndrome: a Mayo Clinic series

onlinelibrary.wiley.com/doi/10.1111/bj…
#leusm #mdssm #DDX41 Mrinal Patnaik Mark Litzow Aref Al-Kali Naseema Gangat

SCIENCE MATTERS!! 🧬
Major win for the #MDSsm field and our patients 🙌🏼🥳 #IPSSM
A huge congratulations & 🙏🏻 to all of you.
A testament to the impact of powerful & well-designed prognostication schemes by brilliant scientists Elli Papaemmanuil, PhD Elsa Bernard et al, combined…

So excited to present the five year follow up results of phase 2 single arm clinical trial conducted MD Anderson Cancer Center evaluating Aza + Rux in MDS/MPN overlap syndromes! #ASH23

ORR : 54%, DoR : 35 months
mOS: 31.8 mo

Link : ash.confex.com/ash/2023/webpr…

#leusm
#mdssm
#mpnsm

Favorable outcomes in MDS and oligoblastic AML-MR after reduced-intensity conditioning allogeneic HSCT with PTCY
nature.com/articles/s4140…
Bone Marrow Transplantation The EBMT Trainee Committee #BMTsm #MDSsm #leusm

I ❤️ my patients and their caregivers. They are the most amazing, brave & kind people I know. What a privilege to take care of #leusm & #mdssm patients. ⁦The James⁩

#ASH23 Highlights #CommunityOnc :

#Myeloma
1. #PERSEUS

2. #IsKia

3. #Bortezomib dosing

CLL Update
4. #SEQUOIA & #ALPINE

cHL Update
5. #SWOGS1826

MF
6. #TRANSFORM1 & #MANIFEST2

1/7

#HemeTwitter #OncTwitter #MedEd #AMLsm #MMsm #MDSsm ASH SWOG Cancer Research Network